Brett Howell

Senior Director, Qsp, Cpms Oncology @GSK

Salisbury, NC, US
MOBILE NUMBERS
+17•••••••55

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WORK HISTORY

Sep 2025 — Present

Senior Director, Qsp, Cpms Oncology @GSK

Charlotte, NC, US

As Senior Director of QSP within CPMS oncology at GSK, I focus on leading a team that is applying quantitative systems pharmacology (QSP) and toxicology (QST) solutions to address key clinical drug development questions, and to facilitate the advancement and approval of new medicines for cancer patients.

EDUCATION

2006 — 2010

University of Florida

Doctor of Philosophy, Chemical Engineering

2002 — 2006

North Carolina State University

Bachelors of Science, Chemical Engineering, Textile Engineering

SKILLS

RPharmacokineticsPharmacodynamicsModeling and SimulationJmpFluorescence SpectroscopySystems BiologyMatlabChemical EngineeringMaple

ABOUT BRETT HOWELL

I currently serve in the role of Senior Director of QSP at GSK within the CPMS Oncology group. My role is to apply QSP to help advance drug development programs and contribute to new cancer treatments.I served as President of QSP Solutions at Simulations Plus Inc. from 2017 to 2024. Simulations Plus works to provide the pharmaceutical industry with in silico software and consulting solutions related to chemical design, drug exposure, safety, and efficacy. My business unit was focused on quantitative systems pharmacology (QSP) and toxicology (QST) modeling to enable therapeutic development. We specialized in oncology, autoimmune disease, fibrosis, complement, liver disease, lung disease, safety, and much more.My educational background and training is in chemical engineering and PBPK/QSP modeling.

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