Julie Huang
Principal Bioinformatics Scientist Ii @Roche
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WORK HISTORY
Principal Bioinformatics Scientist Ii @Roche
Pleasanton, CA, US
Partner with research institutes and oncology hospitals, ensuring satisfactory performance of TMB algorithm.• Assist customers with medical device products by providing support, troubleshooting, and software patch.• Drive project planning and product increment operations, increasing the impact of products prior to launch.• Design data-intensive products for diseases and diagnostics, defining optimal thresholds for classification.• Conduct exploratory data analysis, driving data insights, and building machine learning models prototypes.• Act as a Data Science Expert, organizing meetings with Medical Affair Experts, Product Managers, Business Team Reps, Software Team Tech Leads, and UI Designers, and impacting product roadmap decisions.• Handle the technical requirements for bioinformatics pipeline by integrating BDD, unit, and integration tests.• Build cancer diagnostics panel and algorithm for immune-checkpoint inhibitor patient segmentation.• Offer test cases, documentations, specifications, maintenance, and workshops for internal R&D machine learning techniques, and data visualization tools.• Examine the pattern and prevalence of the novel biomarker in curated clinical patient cohorts and publicly available data sources.• Conduct validation of the preliminary product per FDA guidance, while ensuring acceptable sensitivity, specificity, QC metrics, limit of detection, reproducibility, repeatability, linearity, accuracy and precision.
EDUCATION
High School Affiliated to Fudan University
High School Diploma
Fudan University
Bachelor of Science (B.S.), Biology/Biological Sciences, General
University of Massachusetts Amherst
Doctor of Philosophy (PhD), Population Genomics
SKILLS
ABOUT JULIE HUANG
I am a data science expert adept at analyzing large amounts of information to find patterns and solutions, while building statistical, optimization, and machine learning models. I am equally capable of extracting, analyzing and interpreting large amounts of data from a range of sources, using algorithmic, data mining, artificial intelligence, machine learning, and statistical tools.My career highlights:• Managed the software technical requirements for bioinformatics pipeline by integrating BDD, unit and integration tests, while presenting data-driven analyses, results and methods with data visualization.• Developed various products by applying suitable bioinformatics, machine learning and statistical methods.• Utilized public databases, simulating data to train ML models for predictions, and testing on cell line data.• Effectively trained and validated logistic regression, SVM, SVC, kNN, and random forest ML methods.• Created an algorithm to improve pedigree quality for a program with unsupervised learning technique.• Maintained software that performed whole exome sequencing datasets, while implementing best practices for product life cycle.My academic highlights:• I have completed a PhD in Population Genomics at University of Massachusetts-Amherst.• I have also completed a Bachelor’s degree in Biology at Fudan University.My extracurricular achievements, awards, volunteering, research etc.• 2nd place in the model performance category of Roche Advanced Analytics Data (RAAD) Challenge 2.0.• 1st author of AACR 2019 Conference Poster, co-authoring multiple peer reviewed research articles on prestigious journals.• Assembled sequence of 15 Fusarium genomes, while accounting for pathogenicity of the fungal pathogen. • I am a member of Society for Molecular Biology and Evolution; and Annual Plant Biology Symposium.• I was a Science Ambassador at Dow Agro Sciences, and Exhibition Volunteer at 2010 World Expo Shanghai.My technical skill-stack:• I have extensive knowledge of technologies such as Microsoft Office, Google Workspace, Python, Pandas, NumPy, Scikit-learn, Matplotlib, BeautifulSoup, Git, Perl, Flask, Streamlit, Seaborn, TensorFlow, Conda, SQL, R (Shiny), Jupyter, Linux/Unix, Bash/Shell, and AWK amongst several other tools.My goal and skillset:I have strong product knowledge and intuition, with a dedication to working in a high-performance mode. Looking forward to connect with other ambitious professionals!
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