Zhiwei Wen
siRNA therapeutics, Drug Delivery, Medicinal Chemistry
- Role
- Senior Scientist at City Therapeutics
- Location
- Cambridge, MA, US
- LinkedIn followers
- 500 followers
About Zhiwei Wen
Expertise Summary• Synthetic Organic Chemistry: employing comprehensive synthetic strategies, various purification technologies, and modern instrumental analytical techniques to obtain desired HPLC-grade pure chiral/achiral organic small molecules• Early Drug Discovery and Development: design and synthesis of lead-based ligands for therapeutic targets; collaborative preclinical tests to study efficacy and off-target activities of ligands for structure-activity relationship (SAR) optimization cycles to select drug candidates• G Protein-Coupled Receptors (GPCRs): design and synthesis of agonists and antagonists for GPCRs as well as characterization of their pharmacological properties for treating human diseases• Nucleoside/tide Chemistry: Synthesis and development of nucleoside/tide analogues for their applications in bioconjugation, biosensors, and anticancer and antiviral medicines; preparation of phosphoramidite monomers of nucleoside analogues for solid-phase oligonucleotide synthesis• Research in Multi-disciplinary Research Team: collaborating with computational chemists and biologists from our lab and pharmaceutical companies to develop novel drug candidates• Composing Patents and Peer-reviewed Publications, and Presenting at Scientific Conferences• Mentoring Junior Scientists/Students**Skills• Innovative and practical synthetic strategies: including, but not limited to, transition-metal-catalyzed cross-coupling reactions (Suzuki coupling, Sonogashira coupling, hydroarylation, etc.), microwave-assisted reactions, electrosynthesis, air-sensitive techniques, chiral-resolving-agent-assisted synthesis, etc.• Techniques for purification: preparative HPLC, chiral HPLC, automatic flash chromatography, column chromatography (silica, DEAE–Sephadex®), and preparative thin layer chromatography• Modern instrumental analytical techniques: 1D NMR (1H, 13C,19F, NOE) and 2D NMR (COSY, HSQC, HMBC), HRMS, HPLC, LC-MS, gel electrophoresis, UV spectrometer, FTIR spectrometer, polarimeter, Raman spectrometer; scanning probe microscopy (AFM and STM) • Preclinical tests: solubility tests, HPLC-based lipophilicity tests, chemical stability tests, receptor affinity test using Flow Cytometry• SELEX (selection of DNA aptamer for small molecules): magnetic bead modification, PCR, DNA purification, ssDNA preparation, PAGE analysis, etc• Software (Med. Chem.): SciFinder, Chemdraw, MestReNova, StarDrop, Maestro (Schrodinger) etc.• Maintenance and troubleshooting of HPLC and other instruments in the labs
Experience
Senior Scientist
Apr 2024 — Present · Cambridge, MA, US
siRNA therapeutics, Drug Delivery, Medicinal Chemistry
Education
National Institutes of Health (NIH)
Postdoctoral Fellow , Medicinal Chemistry
Fuzhou University
Bachelor's degree, Chemistry
Chinese Academy of Sciences
Master's degree, Analytical Chemistry
Florida International University
Doctor of Philosophy - PhD, Chemistry
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