Mike Cheng
Process Development Scientist @Abbott
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WORK HISTORY
Process Development Scientist @Abbott
Reviewed batch records to investigate and resolve technique-related issues by identifying root causes and implementing CAPA solutions to ensure consistent, high-quality production of proteins, antibodies, and conjugates.• Collaborated with research and development, operations, quality control, and cross-functional teams to transfer new technologies and products into manufacturing.• Designed studies for scaling up fermentation in E. coli from shake flasks to 1.5–10 L stirred-tank bioreactors and protein purification processes using a specialized platform. Collaborated with R&D and Operations to optimize key parameters. Led production engineering and verification lots to enhance protein yield while ensuring compliance with customer specifications and requirements.• Developed Manufacturing Record Procedures (MRPs). Edited and adapted MRPs from R&D for a seamless transition to GMP manufacturing. Applied redlines and updated versions after each batch, incorporating feedback from Operations and QC.
EDUCATION
Cedars-Sinai Health Sciences University
Health Delivery Sciences
Chinese Academy of Sciences
Microbiology
ABOUT MIKE CHENG
I am an innovative and experienced scientist with 15+ years of expertise spanning discovery, diagnostics, and biomanufacturing in both academic and industry settings. My work translates mechanistic insight into real-world applications across clinical research, assay development, and biotech product innovation. My background includes developing in vivo disease models, analyzing host–microbiome–immune system interactions, and identifying biomarkers for gastrointestinal and infectious diseases. I have led experimental design efforts in antibody/protein workflows, RNA biology, and gene editing, while supporting diagnostic assay development and regulatory/clinical protocols. In industry, I have scaled up microbial fermentation and protein purification workflows, optimized cell-based bioassays, and supported cross-functional technology transfer in GMP-compliant environments. I bring hands-on experience in multiplex qPCR assay development, enzyme and antibody expression and purification, microbiome profiling, and flow cytometry. I am currently seeking new opportunities to apply my expertise in fermentation and biomanufacturing, translational science, antibody discovery, molecular diagnostics, immunology, RNA therapeutics, microbiome research, or core lab operations within innovative biotech or research-driven teams.
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