Zhilan Hu
Principal Scientist, Cell Therapy Group at Genentech
- Role
- Principal Scientist, t Cell Therapy Group at Genentech
- Location
- South San Francisco, CA, US
- LinkedIn followers
- 500 followers
About Zhilan Hu
5 years in T Cell Therapy Analytical group, 12 years in Cell Line Development and 6 years in Immunology Department at Genentech. Experience From T Cell Therapy- Lead analytical development for personalized NeoT program. Lead assay Tech Transfer to internal and external QC personnel, for potency and all flow cytometry-based assays- Independently design, test, and implement quality-based analytic assays to support the characterization and release of cell therapy products- Author SOP test methods and relevant regulatory filings (module 3 section in IND)- Developed G-banding Karyotyping and Isoplexis assay for product characterization- Good understanding of cGMP environment, and Quality by Design (QBD) principles for process and assay development, qualification and validation- Provide technical expertise within project teams and in a matrix environment.Experience From Stable Cell Line Generation- Generated numerous stable cell lines in various types of CHO host and selection systems, in both random and targeted integration hosts- Authored CMC sections for both IND and BLA regulatory filings- Familiar with cell culture bioreactor process development (USP)- Hands-on experience with transiently transfecting Expi293 and CHO cells in small scale high-throughput tubespin and large scale wave bags (5 to 25L)- Hands-on experience with CHO cell engineering such as knocking-out CHOP gene (CHO Protein) by CRISPR/Cas9 technology.General Experience- Managerial experience: managed research associates, lab manager, interns, co-ops, and rotational employees. Conducted weekly 1 on 1 meetings with direct reports for mentoring and guidance on projects- Advised and mentored direct reports on experiment design, data analysis, report and manuscript writing, and presentations- Strong written and verbal communication: first and corresponding author on papers and presented on projects at department meetings and seminars.
Experience
Principal Scientist, t Cell Therapy Group
Feb 2022 — Present · South San Francisco, CA, US
Analytical lead for private Neo T program- Identify and develop unique assays for private Neo T program- Lead analytical development for private Neo T- Lead analytical assay transfer to a new Genentech manufacture facility
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