Yuan Tian
- Role
- Research Scientist, Bioinformatics at Kite Pharma
- Location
- Seattle, WA, US
- LinkedIn followers
- 500 followers
About Yuan Tian
Expertise in using Python and R to analyze high-dimensional bulk and single-cell…
Experience
Research Scientist, Bioinformatics
Jan 2022 — Present
Built machine learning models and conducted survival analysis to discover biomarkers linked to responses to CAR T-cell therapy. • Built PaperGPT, a large language model-driven search and recommendation app for biomedical papers. • Created ReceptorGPT for TCR specificity and structure discovery leveraging protein language models. • Implemented autoencoders using PyTorch for unsupervised analysis of single-cell multi-omic data, generating representations for downstream analyses including clustering, classification, and visualization. • Designed and implemented computational pipelines using Nextflow and Docker on AWS for analyzing bulk DNA-seq, bulk RNA-seq, and scRNA-seq/TCR-seq data from CAR-T preclinical and clinical trials. • Developed bioinformatics web applications using Python and Jupyter for internal use that increase the productivity of research scientists by 100X.
Education
University of Alabama at Birmingham
Doctor of Philosophy (Ph.D.), Microbiology and Immunology
2011 — 2016
Tianjin University
Bachelor’s Degree, Bioengineering and Biomedical Engineering
2007 — 2011
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