Yoav Timsit
Director, Preclinical Safety at Blueprint Medicines
- Role
- Director, Preclinical Safety at Blueprint Medicines
- Location
- Boston, MA, US
- LinkedIn followers
- 500 followers
About Yoav Timsit
Board-certified Project Toxicologist with proven record of assisting lead drug candidate selection and experienced in IND-enabling toxicology assessments and supporting NDA submissions. Currently focused in Oncology, but have prior experience in Cardiovascular & Metabolism, and Musculoskeletal therapeutic areas Expertise: In Vivo Toxicology - 20+ years, including 8 years as Study Director for Investigative Toxicology • In Vitro Toxicology - cellular and biochemical assays • Laboratory Management • Drug Metabolism/DMPK • Animal Models - development and/or implementation of existing models, including genetically-modified • Pharmacology - in vivo & cellular assays, animal models of disease • Nuclear Receptor Biology • Molecular Pathways/Signaling • New Modality Therapeutics - mRNA and mRNA delivery
Experience
Director, Preclinical Safety
Jul 2021 — Present · Cambridge, MA, US
Lung Cancer Franchise Drug Safety Lead authoring key submissions (IND, NDA) and responding to global regulatory inquiries. • Provide quantitative risk assessment from nonclinical data (pharmacology, toxicokinetics, toxicology) supporting clinical development of novel targeted therapies • Directing mechanistic safety strategy for discovery and development projects at Blueprint
Education
McGill University
BSc
1991 — 1995
University of Toronto
PhD
1997 — 2002
University of Toronto
MSc
1995 — 1997
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