Yinzheng Guan
Senior Scientist Iii @Thermo Fisher Scientific
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WORK HISTORY
Senior Scientist Iii @Thermo Fisher Scientific
Boston, MA, US
Analytical Method Development & Implementation:**- Lead analytical development for novel gene therapy modalities including nanobody-ASO conjugates, developing and implementing comprehensive analytical strategies that reduced study timelines by 30% through optimized method selection and validation approaches- Pioneer innovative assay development for intact, total, active, and free ASO quantification using hybridization-based and ligand binding platforms, achieving 10-fold improvement in LLOQ and eliminating matrix interference through systematic buffer optimization and QbD principles- Design and execute analytical method qualification studies across multiple matrices (plasma, brain, muscle), generating robust data supporting regulatory submissions for 2 programs advancing to IND-enabling studiesDevelop and optimize protein assays on a variety of platforms including Simoa, MSD- Evaluate and implement new analytical technologies within cross-functional teams, serving as primary analytical representative on 3 discovery and preclinical development programs- Serve as analytical lead on GLP/GCLP regulated studies, managing external CRO relationships and ensuring analytical method transfer and compliance with regulatory standards- Maintain comprehensive LIMS and ELN documentation for all analytical methods and validation activities**Cross-functional Leadership & Strategy:**- Provide strategic analytical guidance to cross-functional teams, influencing candidate selection and milestone transitions for nanobody-ASO programs- Coordinate with internal bioanalytical, protein analytics, and discovery teams to ensure timely reagent generation and method optimization, maintaining 95% on-time delivery for critical path studies- Lead biomarker strategy development for neurology and rare disease programs, establishing analytical endpoints that supported regulatory discussions and informed clinical trial design
EDUCATION
Zhejiang University
Bachelor's degree, Biotechnology
Rutgers University
Master's degree, Computational Neuroscience
Temple University - Lewis Katz School of Medicine
Master's degree, cardiovascular physiology
Cleveland State University
Doctor of Philosophy - PhD, Neuroscience/Alzheimer's Disease
ABOUT YINZHENG GUAN
With over 10 years of research experience in biochemistry, bioanalytical, genetics, molecular biology, ADME, and bioinformatics, I am a Scientist II at Azenta Life Sciences, a leading biotech company that provides innovative solutions for drug discovery and development. In my current role, I provide study support focusing on Next-Generation Sequencing (NGS) assays, perform standard and specialized DNA/RNA library preparation workflows, and carry out custom Single-Cell and ATAC-seq preps utilizing 10X genomics and illumina platforms. I also create SOPs for laboratory sequencing workflows, work closely with clients and study managers to communicate project progress and results, and provide technical guidance to junior scientists in project teams.My core competencies include Cell-Based Assays, High Throughput Screening, Flow Cytometry, NGS, and Bioinformatics. I have a strong background in neuroscience and cardiovascular physiology, and have conducted cutting-edge research on brain metabolism, neuronal modeling, and anti-aging effects of Klotho on neurodegenerative diseases. I have published multiple peer-reviewed articles, presented at international conferences, and received awards and fellowships for my academic achievements. I am a detail-oriented researcher with proven problem-solving, project management, and presentation skills. I excel at collaborating with multidisciplinary teams and adapting to changing project demands and timelines. I am passionate about applying my diverse skillset to impactful problems and advancing the scientific knowledge and innovation in the biotech industry.
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