Yimin Huang

About Yimin Huang

With over eight years of dedicated experience in antibody discovery and protein engineering, my mission is to innovate therapeutic solutions at Biogen. My expertise in AI-driven developability prediction and high-throughput antibody screening underpins my ability to deliver species-cross-reactive antibodies. At Biogen, my commitment aligns with advancing healthcare through cutting-edge research, and I thrive in environments that value collaboration and diversity in thought.Since joining Biogen, I have significantly improved antibody prediction accuracy by implementing balanced data in AI/ML models and expedited the identification of high-affinity antibodies using next-generation sequencing. My role involves managing the entire cycle from discovery to down-selection, processing over 300 antibodies weekly. These skills, coupled with a robust background in bioinformatics and purification techniques, enable my team to propel forward in developing innovative antibody-based therapies.

Experience

1. Scientist, Antibody Discovery

   Biogen

   Jan 2022 — Present · Cambridge, MA, US

   Yeast display to discover species-cross-reactive therapeutic antibodies.• Immune repertoire NGS analysis from immunized animals, identifying high-affinity antibodies within two weeks.• Built custom germline reference for humanized mouse NGS analysis.• Developed AI/ML model to predict antibody developability, increasing the prediction accuracy from 69% to 85% by using balanced data.• High throughput antibody expression and purification with Hamilton liquid handler (300 antibodies per week).• Evaluation of antibody affinity, specificity and developability.• Lead antibody characterization and down-selection (from hundreds to ten).

Education

• The University of Texas at Austin

  Doctor of Philosophy - PhD, Antibody and Protein Engineering

  2015 — 2020

• Huazhong University of Science and Technology

  Bachelor of Medicine, Clinical Medicine

  2007 — 2012