Yiannis Savva
Director @Shape Therapeutics Inc
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WORK HISTORY
Director @Shape Therapeutics Inc
Head of RNA Editing and Payload Technology
EDUCATION
Brown University
Master of Arts (M.A.), Molecular Biology, Cell Biology, and Biochemistry
Central Connecticut State University
Bachelor of Science (B.S.), Cellular and Molecular Biology
Brown University
Doctor of Philosophy (Ph.D.), Molecular Biology, Cellular Biology and Biochemistry
SKILLS
ABOUT YIANNIS SAVVA
Molecular biologist with over 20 years of expertise in RNA processing and modification, specializing in RNA editing and splicing. Passionate about advancing therapeutic RNA editing as a cutting-edge approach to correct specific genetic mutations for a wide range of disorders. • Currently focused on designing next-generation guide RNAs (gRNAs) to harness the endogenous RNA editing machinery (ADAR-based) for precise \"RNA fixes,\" including targeted point mutation corrections, modulation of protein-protein interactions, exon skipping, and gene expression regulation for therapeutic applications. • Developed genetically engineered models, including animal models for human diseases like epilepsy and ALS, to investigate RNA structure and function. • Key contributor to 23 peer-reviewed publications (1,683 citations, h-index: 14) and 29 patents. • Recognized for strong leadership through extensive teaching, mentorship, and scientific editorial roles. • An abstract artist working with acrylic and resin on canvas and wood, blending the creativity of science and art. Both fields fuel my passion for problem-solving, organization, and innovation, driven by a desire to create and share unique, impactful work with the world.
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