Yasoda Krushna. Kakinada Krushna Kakinada

WORK HISTORY

EDUCATION

ABOUT YASODA KRUSHNA. KAKINADA KRUSHNA KAKINADA

Process Development Scientist ProfileProfessional Experience and Role• Process Development Scientist | API & CDMO | Process R&D• Process Development R&D Scientist with 6+ years of hands-on experience supporting API and CDMO projects from early laboratory development through pilot, kilo-lab, and commercial manufacturing.• Experienced across generic and innovative APIs, including oncology and non-oncology molecules, with a strong focus on building robust, scalable, and regulatory-compliant processes.• Currently working as Research Associate II – Process R&D at Sai Life Sciences Ltd, contributing to end-to-end process development, optimization, scale-up, and technology transfer under GLP and cGMP environments.Key Areas of Expertise• Core Expertise• Route scouting, literature & patent evaluation, and feasibility studies• QbD-driven development and DoE-based process optimization• Impurity profiling, control strategies, and scale-up execution• Process risk assessment, safety evaluation, and scale-up troubleshootingSynthetic Chemistry and Scale-Up Capabilities• Synthetic Chemistry & Scale-Up• Extensive experience in multi-step organic synthesis from gram to kilogram scale• Strong hands-on expertise in oxidation, reduction, acid–amine coupling, and protection–deprotection strategies• Proficient in handling highly reactive and pyrophoric reagents including n-BuLi, LAH, DIBAL-H, Raney Nickel, Pd/C, and BH₃-THFAnalytical Skills and Equipment Knowledge• Analytical & Equipment Proficiency• NMR interpretation (¹H & ¹³C), LC-MS, HPLC, and reaction mechanism analysis• Purification techniques: column chromatography, flash chromatography, distillation, and crystallization• Experience with batch and continuous processing equipment, including autoclaves, tubular reactors, Radley reactors, parallel synthesis reactors, and rotary evaporatorsCollaboration and Documentation Contributions• Collaboration & Documentation• Active contributor to technology transfer packages, batch records, SOPs, CAPA investigations, vendor qualification, and CMO coordination• Strong collaboration with manufacturing, QA, and regulatory teamsTechnical Skills Overview• Technical Skills & Professional DevelopmentTechnical Proficiency• Proficient in Excel, ChemDraw, electronic lab notebooks, technical documentation, and scientific presentationsCommitment to Growth and Improvement• Continuously upskilling through certifications in manufacturing, supply chain, and AI, with a mindset focused on process efficiency, yield improvement, quality, and regulatory readiness