Yao Chen

WORK HISTORY

EDUCATION

SKILLS

ABOUT YAO CHEN

Analytical lead or developed assays for more than 10 major projects ranging from pre-clinic to phase II b, with APIs spanning from complex glycoproteins, vaccines, monoclonal antibodies, fusion proteins, single domain antibodies to small molecules, coordinated orthogonal analytical support (UPLC-MS, SDS-CE, cIEF, ELISA, GC-FID, etc.) for up/down stream processes, formulation/stability and potency.• Supervised multiple industry co-op students, associate scientist, graduate students on spent media analysis, formulation excipient (PS20, Poloxamer, amino acids) quantifications, drug degradants and impurity analysis, trans-membrane drug transporter protein quantifications, and providing LC-MS trainings, resulting several conference posters.• Protein characterization with various chromatography (SEC, HILIC, RP, IXC, GC) and capillary electrophoresis (cIEF and CE-SDS).• Seven years of experience in (low/high-resolution) mass spectrometry based DIA, DDA, PRM, or MRM techniques in discovering and quantifying proteins, peptides, metabolites, drug-degradants, and synthetic impurities in complex biological systems (up/down-stream purification processes, cell lysates, human liver homogenates, human urine, blood, and fecal materials).• Proficient in python and C++ facilitating MS data analysis. Coded Global Characterization Data Processing Site and established related protein post-translational modification (PTM) analysis methods allows rapid and consistent process of large amount of protein PTM data (mAbs, 2019, VOL. 11, NO. 6, 1089–1100).