Yao Chen

About Yao Chen

Analytical lead or developed assays for more than 10 major projects ranging from pre-clinic to phase II b, with APIs spanning from complex glycoproteins, vaccines, monoclonal antibodies, fusion proteins, single domain antibodies to small molecules, coordinated orthogonal analytical support (UPLC-MS, SDS-CE, cIEF, ELISA, GC-FID, etc.) for up/down stream processes, formulation/stability and potency.• Supervised multiple industry co-op students, associate scientist, graduate students on spent media analysis, formulation excipient (PS20, Poloxamer, amino acids) quantifications, drug degradants and impurity analysis, trans-membrane drug transporter protein quantifications, and providing LC-MS trainings, resulting several conference posters.• Protein characterization with various chromatography (SEC, HILIC, RP, IXC, GC) and capillary electrophoresis (cIEF and CE-SDS).• Seven years of experience in (low/high-resolution) mass spectrometry based DIA, DDA, PRM, or MRM techniques in discovering and quantifying proteins, peptides, metabolites, drug-degradants, and synthetic impurities in complex biological systems (up/down-stream purification processes, cell lysates, human liver homogenates, human urine, blood, and fecal materials).• Proficient in python and C++ facilitating MS data analysis. Coded Global Characterization Data Processing Site and established related protein post-translational modification (PTM) analysis methods allows rapid and consistent process of large amount of protein PTM data (mAbs, 2019, VOL. 11, NO. 6, 1089–1100).

Experience

1. Principal Scientist

   Inhibrx Biosciences, Inc

   Feb 2026 — Present

Education

• The University of Kansas

  Master of Science (MS), Pharmaceutical chemistry

  2011 — 2013

• The University of Kansas

  PhD Candidate, Pharmaceutical Chemistry

  2011 — 2016

• Emporia State University

  Bachelor of Science (BS), cell biology and microbial biology

  2008 — 2011

• Emporia State University

  Bachelor of Science (BS), Biochemistry and Molecular Biology

  2008 — 2011

Skills

• Mass Spectrometry
• Biochemistry
• Protein Chemistry
• Uv/Vis Spectroscopy
• Liquid Chromatography-Mass Spectrometry (Lc-Ms)
• Biotechnology
• Enzyme Kinetics
• Lc-Ms
• Bioanalysis
• Fluorescence
• Cell Culture
• Pcr
• Western Blotting
• Molecular Biology
• Uv/Vis
• Hplc
• Analytical Chemistry
• Drug Metabolism
• Chemistry
• Cell Biology