Xiaoyi Eileen Wang

Associate Scientist, Peptide Chemistry @BioNTech SE

Gaithersburg, MD, US

Streamlined end-to-end high-throughput workflows for peptide antigen synthesis, purification, lyophilization, and QC, enabling consistent biweekly delivery of 384 peptides or three full patient-specific mutanome libraries per month.• Developed and implemented an automated mRNA synthesis platform for top TCR clones using in vitro transcription and magnetic bead purification, integrating Formulatrix FAST and Agilent BRAVO liquid handling systems to ensure consistency and scalability.• Optimized 384-well TCR functional screening using NFAT-luciferase Jurkat reporter cells and functional avidity assays, significantly enhancing algorithm-based identification of CD8+/CD4+ tumor-reactive TCRs across diverse antigen targets.• Collaborated with the QC department to investigate immune cell batch contamination and antigen degradation following ICH guidance, identifying root causes through UPLC-MS analysis and implementing corrective actions to restore batch integrity.• Negotiated cost-saving agreements with vendors, reducing instrument and lab consumable expenses by 20%, while cultivating strong partnerships to expedite maintenance and repair services—enhancing lab efficiency and uptime.• Interpreted experimental data, authored detailed technical reports, and delivered biweekly presentations to the Research Director; selected to present key project milestones at company-wide transatlantic scientific meetings.• Completed 16 Harvard Medical School online courses (average score: 95%) across disciplines including immunology, pharmacology, and genetics, applying new knowledge to deepen strategic understanding of corporate R&D pipelines and clinical trial positioning.• Mentored summer interns in experimental design, instrumentation, and data interpretation; supported onboarding and cross-training of junior team members, fostering team productivity and knowledge transfer.

Institute of Technology, Tallaght

Bachelor of Science (BSc)

University of Sydney

Doctor of Philosophy

Nanjing University of Technology

Bachelor of Science (BSc)

Imperial College London

Master of Research