Xiaoming Lu

WORK HISTORY

EDUCATION

SKILLS

ABOUT XIAOMING LU

Translational scientist with 10+ years of experience in gene editing, off-target safety assessment, and autoimmune genetics. Expertise in vector biology, CRISPR-based therapeutic assessment, and high-throughput screening using human, mouse, and NHP cell models. Proven ability to lead cross-functionalteams and manage discovery-stage programs in collaboration with CROs and internal partners. Deep experience with data-driven therapeutic optimization and in vivo/in vitro assay developmentExperience highlights- Expert in gene editing off-target safety assessment, building platforms including off-target nomination, confirmation and functional validation- Lead a cross-functional effort to build a rapid-turnaround ddPCR screening system with CRO, automation, eLN (Benchling), app integration, and advanced data visualization- Lead projects to develop and optimize cell models derived from human, mouse, and non-human primates (NHP) to facilitate mutant screening and analysis- Deep understanding in the development of high-throughput screening assays, with a particular focus on massively parallel reporter assays- Deep understanding of human genetics with a focus on autoimmune diseases utilizing on genome-wide association studies (GWAS), fine mapping, statistical analysis, and MPRA etc to identify and validate causal genetic variants- Proficient in bioinformatics pipeline development, leveraging R, Python, and Linux tools for comprehensive data analysis.