Weslyn Ward Friley

About Weslyn Ward Friley

Experienced bioanalytical director and research scientist with 20 years\' experience applying principles of ADME-Tox and bioanalytical chemistry to drug discovery and development programs for both small and large molecules (biologics). Experience in drafting and responding to regulatory submissions (NCE or medical device) for LCMS and LBA programs, including immunogenicity, metabolomics, and routine quantification. Highlights: Established new contract research laboratories for bioanalytical services and built contract service facilities from the ground up; Designed and implemented in vitro assays to predict in vivo / in vitro correlation and rank order compounds for discovery programs based on ADME-tox properties; Established a streamline approach for method development to meet the needs of fast pace preclinical screening, including the implementation of robotics for high throughput sample preparation.

Experience

1. Senior Research Scientist

   Ppd

   Apr 2021 — Present · Richmond, VA, US

   Oversees complex analytical development and/or specialty technologies projects to create new analytical methods, enhance existing methods, and transfer client-provided methods using multiple instrumentation techniques and multiple detection techniques. Provides technical and regulatory consulting to internal groups and clients about their programs. Provides technical guidance and mentorship to senior staff members in performing laboratory activities. Routinely acts as the technical project leader for multiple projects, interacts with clients to provide technical project updates, reviews and evaluates data, and writes reports. This position may handle hazardous waste. Can work with GLP and/or GCP studies and are GxP trained. May serve as principal investigator.

Education

• Virginia Tech

  B.S. Biochemistry, B.A. Chemistry, Biochemistry and Organic Chemistry

  2000 — 2003

• Duke University

  Doctor of Philosophy - PhD, Chemistry

  2003 — 2008

• Duke University

  Ph.D., Bioanalytical and Biological Chemistry

  2004 — 2008

Skills

• Good Laboratory Practice (Glp)
• Pharmacokinetics
• In Vitro
• Drug Metabolism
• Drug Development
• Bioanalysis
• Liquid Chromatography-Mass Spectrometry (Lc-Ms)
• Biochemistry
• Protein Chemistry
• Hcv
• Validation
• Mass Spectrometry
• Analytical Method Validation
• Glp
• Drug Discovery
• Allometry
• In Vivo
• Chemistry
• Lc-Ms
• Phoenix
• Life Sciences
• Pk/Pd
• Tissue Culture
• Transporters