Wenguo Gao
Principal Research Associate at Moderna
- Role
- Principal Research Associate at Moderna
- Location
- Cambridge, MA, US
- LinkedIn followers
- 500 followers
About Wenguo Gao
Principal Research Associate at Moderna with expertise in developing and qualifying GMP-compliant bioanalytical and cell-based assays (fluorescence, ADA ELISA, LC-MS/MS) to advance mRNA and Prime Editing therapeutics, driving PK/PD-guided decisions across 50+ constructs and 14 in vivo studies. Passionate about leveraging automation and robust SOPs to ensure high-throughput, QC-ready data that accelerate bench-to-bedside translation.
Experience
Principal Research Associate
Mar 2024 — Present · Cambridge, MA, US
Gene Editing Program• Advance gene-editing therapeutic development, by screening guide RNAs and delivering Cas9/reverse transcriptase mRNA constructs in vitro and in vivo to assess Prime Editing efficiency.• Increase assay throughput and data quality, by performing high-efficiency transfections in primary hepatocytes and HEK293FT/Hep3B cells, followed by LNP retention and biomarker profiling.• Build robust PK/PD datasets, by developing LC-MS/MS and Jess-based assays to quantify editing machinery and target proteins, ensuring data consistency across 14 in vivo studies completed within 6 months.
Education
Stony Brook University
Bachelor's, Biomedical Engineering
2013 — 2017
Stony Brook University Graduate School
Master's degree, Biomedical/Medical Engineering
2017 — 2018
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