Venkat Dharmarajan

About Venkat Dharmarajan

10 years of experience in protein biochemistry and biophysics with special emphasis on pharmaceutically relevant protein targets like Kinases, Nuclear receptors, histone methyltransferases, and GPCRs. Comprehensive experience in application of structural and biophysical tools to investigate the molecular details of protein-ligand interactions to support structure based drug design. Strong collaborator and contributor to project strategy, experimental design, and influenced project directions through decision-enabling data presentations. Proven track record of scientific excellence (author or co-authored more than 30 peer reviewed publications) and ability to work in cross functional teams to deliver first in class science. Key Skills: Protein-protein and Protein-ligand interactions (ITC, MST, AUC, SEC-MALS, CG-MALS, FP, TR-FRET, AlphaScreen, DSF, Octet BLI), Molecular Biology (Construct design, cloning, expression and purification using multiple hosts E.Coli, Insect cells), Mass Spectrometry (Hydrogen-Deuterium Exchange-Mass Spectrometry- HDX-MS, Intact and native MS, Bottom-up Proteomics), Macromolecular Crystallography, Structure-based drug design, Mechanistic Enzymology (assay development and kinetics).

Experience

1. Principal Investigator

   Incyte

   May 2025 — Present · US

Education

• Anna University Chennai

  Bachelor of Technology (B.Tech.), Industrial Biotechnology

  2000 — 2004

• Syracuse University

  PhD, Biochemistry, Biophysics and Molecular Biology

  2005 — 2012

Skills

• Pcr
• Elisa
• Lifesciences
• Purification
• Protein Expression
• Isothermal Titration Calorimetry
• Biochemistry
• Molecular Biology
• Protein Chemistry
• Molecular Cloning
• Assay Development
• Biophysics
• Gel Electrophoresis
• Biology
• Enzymes
• Biotechnology
• Protein Purification
• Hydrogen Deuterium Exchange Mass Spectrometry
• Cell Culture
• X-Ray Crystallography
• Fplc
• Radioligand Binding
• Western Blotting
• Sds-Page
• Electrophoresis
• Structural Biology