Tristan Maurer

About Tristan Maurer

Current Roles:Leader of Translational Modeling & Simulation group (20 Ph.D. level scientists) providing PBPK, PKPD, Systems Pharmacology, machine learning and cheminformatic expertise in support of drug discovery and early clinical development across all therapeutic areas.Member of the Pharmacokinetics, Dynamics and Metabolism leadership team responsible for scientific strategy and operations underwriting the delivery of Pfizer\'s small and large molecule portfolio. Associate Editor for Frontiers in Pharmacology, Translational Pharmacology SectionExpertise:In depth knowledge of the mechanisms of drug disposition and pharmacology and the experimental methods used to elucidate such mechanisms in support of drug discovery and development.Development and application of quantitatively rigorous and biologically-based methods to predict human pharmacokinetics & pharmacodynamics from preclinical data (e.g. chemical structure, ADME, drug-drug interactions, effective dose/exposure, pharmacological and toxicological response, therapeutic index)Experience Implementation of quantitative drug design and early clinical development strategies in a highly matrixed, multidisciplinary drug discovery enviroment (e.g. med chem, biology, DMPK, drug safety, stats, clinical pharmacology). Discovery of both small and large molecule therapeutics across multiple therapeutic areas including: cardiovascular and metabolic diseases, inflammation & immunology, rare diseases, neuroscience, osteoporosis, anti-infectives and oncology. Development and execution of world-wide collaborative research with leading academic institutions and in mentoring graduate students and industrial post-doctoral candidates. Authorship of over 70 publications covering areas of rational drug design; small molecule brain penetration; in vitro scaling; drug metabolism; mechanism-based PBPK, PKPD and systems pharmacology modeling; application of quantitative pharmacokinetic & pharmacodynamic predictions in drug discovery; and quantitative predictions of drug-drug interactions arising from competitive inhibition, inactivation and induction. Google Scholar: & hl=en

Experience

1. Vice President of Scientific Research

   Pfizer

   Nov 2023 — Present · Cambridge, MA, US

   Head of Translational Modeling and Simulation, Department of Pharmacokinetics, Dynamics and Metabolism

Education

• The University of Georgia

  Doctor of Pharmacy - PharmD, Clinical Pharmacy

  1986 — 1993

• University at Buffalo

  PhD, Pharmaceutics and Drug Design

  1994 — 1999

• Heritage High School (Conyers, GA)

  College/University Preparatory and Advanced High School/Secondary Diploma Program

  1981 — 1986

• University of Georgia College of Pharmacy

  Doctor of Pharmacy - PharmD, Pharmacy

  1986 — 1993

• University at Buffalo Pharmacy and Pharmaceutical Sciences

  PhD, Pharmaceutics and Drug Design

  1994 — 1999

Skills

• Drug Metabolism
• Metabolism
• Clinical Development
• Adme
• Drug Design
• Diabetes
• Dmpk
• Lifesciences
• Biotechnology
• Lead Optimization
• Oncology
• Pharmacology
• Translational Medicine
• Clinical Pharmacology
• Translational Research
• Lead Change
• Life Sciences
• Drug Discovery
• Pharmacokinetics
• Pharmacodynamics