Tong Chen
Mass spectrometry | Liquid/gas chromatography | Bioinformatics
- Role
- Analytical R & d Researcher at Merck
- Location
- Ithaca, NY, US
- LinkedIn followers
- 500 followers
About Tong Chen
Result-oriented analytical biochemist with 5+ years of experience leading proteomics and LC-MS projects in translational neuroscience. Collaborated on major successful projects with Merck & Co. and Weill Cornell Medicine. • Expert in LC-MS, data integration, and bioinformatics-driven biomarker discovery. • Compelling communicator, engaging broader scientific community via publications, presentations, and outreach.
Experience
Analytical R & d Researcher
Jun 2025 — Present
Developing imaged capillary isoelectric focusing coupled with ultraviolet detection and mass spectrometry (icIEF-UV/MS) methods for in-depth charge variant characterization of highly glycosylated and sialylated Fc fusion proteins, enabling safe and effective therapeutics for patients. • Accelerating biologics pipeline development by exploring enzymatic treatments to reduce sample complexity and testing different mastermix components, buffers, and conditions, resulting in improved charge variant resolution.• Utilizing biopharma data interpretation softwares for MS data analysis and charge heterogeneity profiling, including Xcalibur, SCIEX Biologics Explorer, Intabio ZT Analysis software, FreeStyle.• Collaborating with cross-functional teams to support MS method development, data interpretation, and biotherapeutic quality assessment for drug product characterization.
Education
Zhejiang University
Bachelor's degree
2016 — 2018
Cornell University
Doctor of Philosophy - PhD
2020 — 2025
Cornell University
Bachelor's degree
2018 — 2020
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