Theresa Hillery

About Theresa Hillery

As a Senior Scientist specializing in LC/MS/MS method development and bioanalysis, I bring extensive experience supporting both biotech and pharmaceutical discovery portfolios across diverse therapeutic areas. My work spans small molecules, biologics, and oligonucleotides,(ELISA & MSD) with a focus on generating high-quality data to inform decision-making from early discovery through development. I have designed and executed a wide range of in vivo and in vitro studies—including pharmacokinetics, oral bioavailability, toxicokinetics, protein binding, plasma stability, and mechanistic ADME profiling using CYP enzymes, hepatocytes, microsomes, CaCo2 assays, and radiolabeled approaches. These efforts have been central to optimizing drug candidates and advancing them through key milestones. Beyond the bench, I lead cross-functional initiatives with a strong foundation in project management—aligning scientific strategy with program objectives, managing timelines and budgets, and ensuring seamless execution. I also have extensive experience managing outsourced nonclinical (GLP) and clinical (GCP) bioanalytical studies with CROs across the U.S. and internationally, driving quality and compliance in regulated environments. I’m currently expanding my leadership and business strategy skills through an MBA at Babson College. Known for my scientific rigor, collaborative spirit, and solution-oriented mindset, I’m passionate about translating complex data into actionable insights and working across disciplines to move promising therapies forward. I’m always open to connecting with others who share a passion for innovation in drug development and exploring opportunities to make a greater impact in human health. Technical specialties: LC/MS, CRO/vendor management, method development, pharmacokinetics, biomarkers, bioanalytical strategy, regulatory support.

Experience

1. Senior Scientist

   Pfizer

   Jan 2022 — Present · Andover, MA, US

   Provided “fit-for-purpose” laboratory assay support, method development, validation and outsourcing activities for small molecule biomarkers while applying regulatory and compliance standards. •Optimized the processing of FFPE samples by ultra-high pressure (Barocycler) extraction technique and increased sample prep throughput utilizing plate-based automation (Kingfisher Apex).•Determined best assay conditions for protein quant of protein lysates extracted from FFPE samples.•Applied DIA MS methodology (Orbitrap) to analyze FFPE samples.•Evaluated peptide sequences across 6 pre-clinical species to identify conserved regions for the development of targeted LC-MS assays.•Implemented changes to increase throughput for an online anti-peptide LC-MS assay to detect low abundant peptides in urine

Education

• Babson F.W. Olin Graduate School of Business

  #EntrepreneurialLeadership

  2023 — 2024

• Franklin Pierce University

  BA