Tasdique Quadery

About Tasdique Quadery

HIGHLIGHTS• Medicinal chemist with a strong background in executing multi-step (>15) organic synthesis.•Experienced in conducting critical process parameter studies for chemical processes.• Expert in drug-discovery projects in the \"Exploratory\",\"Hit to lead\", and \"Lead optimization\" phases.• Worked in a very fast-paced environment. • Skilled in the synthesis of PROTACs and modified nucleosides.• Scale-up synthesis of 100 g final product for preclinical studies.• Proficient in catalytic, organometallic chemistry, peptide-coupling, regioselective, ring formation reactions, protecting group chemistry, etc.• Expert in normal phase and reverse phase column chromatography, • Skilled in the use and data interpretation of analytical instruments NMR, HPLC, UPLC, LC-MS, etc.• Experienced in structure-based drug design and ligand-based drug design. •Worked on drug discovery projects in CNS diseases, cancer, and nucleoside triphosphates.• Expert in computational programs such as Schrodinger Drug Discovery Suite, MOE, PyMOL, ChemDraw, etc. • Expert user of Electronic lab notebook (ELN), Chromeleon, Empower, OpenLynx, Scifinder, Endnote, etc.• Proficient in the analysis, interpretation, and visualization of the results of small-molecule drug discovery projects.I enjoy working as part of a team to solve complex scientific problems that contribute to improving human health. My doctoral research was focused on the design and synthesis of microtubule targeting agents (MTAs), Receptor Tyrosine Kinase inhibitors, Antifolates, and PROTACs for cancer.

Experience

1. Senior Research Scientist, Chemical Development

   Curia

   Apr 2025 — Present · Albany, NY, US

   Identified Critical Process Parameters (CPPs) by screening 20+ reaction conditions with the Easy-Max reactor to enable successful scale-up of a Suzuki coupling for manufacturing operations.•Optimized a scalable process through catalyst screening, identified a cost-effective and safer catalyst that improved reaction yield, reduced catalyst loading, and lowered raw-material costs while ensuring suitability for bulk synthesis and GMP manufacturing.•Developed and validated a palladium removal strategy in a scale-up process.• Served as a technical liaison to the Business Development team, leading the preparation of scientifically sound RFP responses within tight deadlines.

Education

• University of Dhaka

  B. Pharm., Pharmacy

  2009

• Duquesne University

  Doctor of Philosophy - PhD, Medicinal Chemistry

  2020

• Faujdarhat Cadet College

  HSC

  1998 — 2004

• University of Dhaka

  M. Pharm., Pharmaceutical Chemistry (MS in Life Sciences)

  2011

Skills

• Chromatography
• Schrodinger
• Uv/Vis Spectroscopy
• Hplc-Ms
• Organic Chemistry
• Flash Chromatography
• Maestro
• High-Performance Liquid Chromatography (Hplc)
• Moe
• Drug Design
• Medicinal Chemistry
• Lead IT
• Nuclear Magnetic Resonance (Nmr)
• Discovery Studio
• Molecular Modeling
• Organic Synthesis