Suzanne Jacobs

Distinguished Scientist, Gene Therapy @Sanofi

Genomic Medicine Unit, Translational Cluster • Project head for preclinical gene therapy program • Leads and manages direct reports and works transversally with research teams responsible for designing and testing candidate gene therapy constructs, assay design and optimization, and processing and analyzing samples from preclinical studies. • Collaborates with representatives from CMC, preclinical safety, biomarkers, clinical bioanalysis, regulatory, legal, and clinical development teams to advance program through preclinical milestones and IND-enabling studies • Establishing and leading new target ID efforts for genomic medicine • Collaborates with precision medicine and computational biology teams on genomics-based approach to identify genetically validated targets for prioritized indications • Responsible for milestone transition documents and presentations for research leadership • Development of in vitro and in vivo models • Designs exploratory preclinical studies to establish delivery, biodistribution, transgene expression, target engagement, efficacy, persistence, and tolerability of gene therapy candidates • Contract with and manage CROs to conduct preclinical studies, process and analyze study samples and data, and prepare study reports