Stephen Sciuto
Application Development Engineer | LC-MS/MS | Oligonucleotide CQAs | Intact mass analysis | Peptide mapping
- Role
- Applications Development Engineer - Biopharma at Agilent Technologies
- Location
- Santa Clara, CA, US
- LinkedIn followers
- 500 followers
About Stephen Sciuto
I am a mass spectrometry expert with 11 years experience operating and troubleshooting MS hardware. Currently I am an Application Scientist at SCIEX, where I use my background in proteomics and biologics to design customer workflows in Biologics Explorer software. Previous features include site-specific glycan localization using peptide mapping, disulfide bond detection, isomer differentiation using EAD, and intact mass analysis of mAbs, IdeS fragments, and ADCs. Prior to SCIEX, I was a Mass Spectrometry Technologist at the Hospital for Sick Children. In this role I developed considerable expertise in the operation of Orbitrap-based mass spectrometers (e.g. Orbitrap Fusion Lumos with and without UVPD, Q-Exactive HF-X, Q-Exactive, and Orbitrap Elite). Designed customized workflows from sample preparation to MS acquisition and processing to identify the number of proteins in a sample, as well as targeted approaches using parallel reaction monitoring (PRM).
Experience
Applications Development Engineer - Biopharma
May 2023 — Present · Santa Clara, CA, US
Acts as a subject matter expert for the operation, troubleshooting, and maintenance of Agilent LC-MS instrumentation-Performs method development on biopharma applications such as oligonucleotide sequence confirmation, target plus impurities, intact mass analysis, peptide mapping, and released glycans workflows on the 6545XT AdvanceBio LC/Q-TOF and Revident LC/Q-TOF system-Assists R&D teams in algorithm and software development for new products-Generates marketing collateral through application notes that showcases Agilent instrumentation in the biopharma market
Education
University of Toronto
Doctor of Philosophy (PhD), Biological Mass Spectrometry
2011 — 2017
Western University
Bachelor of Science (Hon. B.Sc.), Chemistry
2007 — 2011
Skills
- Mass Spectrometry
- Analytical Chemistry
- Fluorescence Spectroscopy
- Computer Programming
- Spectroscopy
- Chemistry
- Separations
- Dna
- Programming
- Experimentation
- Laboratory
- Uv/Vis
- Scientific Writing
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