Stanley K. A. Opare
Computational Chemist Ml Engineeer @Enveric Biosciences, Inc
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WORK HISTORY
Computational Chemist Ml Engineeer @Enveric Biosciences, Inc
CA
During my tenure at Enveric Biosciences as a Computational Chemist, I specialized in leveraging molecular docking techniques to design serotonin-based small molecules targeting Serotonin receptors, particularly 5-HT2A and 5-HT1A. My focus was on reducing the hallucinogenic effects of psychedelic drug candidates, a pivotal step in advancing safe therapeutic options. Utilizing molecular dynamics simulation, I predicted binding modes for potential hallucinogenic and non-hallucinogenic molecules, contributing significantly to our understanding of their interaction mechanisms.Transitioning to a role as a Machine Learning Engineer, I applied my analytical acumen to build predictive toxicology models using the tox21 dataset. Achieving an accuracy of approximately 80%, these models were instrumental in assessing the safety profile of compounds. Furthermore, my efforts extended to developing predictive models for ADME properties, enhancing our capability to evaluate drug-likeness and pharmacokinetics.My collaborative work with pharmaceutical, biochemistry, and chemistry teams culminated in the selection of EB-003 as the Lead Drug Candidate from the EVM301 Series. This milestone marked a significant achievement in our pursuit of innovative compounds, positioning EB-003 for subsequent human clinical studies. My experience at the intersection of computational chemistry and machine learning reflects a commitment to pioneering advancements in drug discovery and development.My contributions at Enveric Biosciences not only advanced our understanding and development of novel therapeutic compounds but also led to the filing of a provisional patent. This patent embodies the innovative approach and significant scientific breakthroughs achieved in our research, underscoring my commitment to pioneering advancements in drug discovery and development.
EDUCATION
Kwame Nkrumah University of Science and Technology
Bachelor of Science - BS, Computational Science
Southern Alberta Institute of Technology (SAIT)
Certificate, Applied Machine Learning
University of Calgary
Doctor of Philosophy - PhD, Computational Science
University of Toronto
Certificate, Full Stack Development
ABOUT STANLEY K. A. OPARE
Strong team player with experience in working with medicinal chemists, biochemists and other scientists resulting in 5 publications (6th publication pending acceptance) and lab grant funding. Knowledgeable innovator with expertise in computer aided drug design and discovery (CADD) approaches such as quantum mechanics, molecular dynamics, homology modeling and multiple parameter optimization methods. This resulted in the design of lead ligands (drugs) that hold promise to cure/treat Alzheimer\'s disease. Strong programming language, Python which I have used to for modeling, data-mining and analyzing of the outputs after molecular dynamics simulations. Have utilized computational tools such as VMD, Pymol, GaussView, MOE, Hex Docking, Molden, AutoDock, Gromacs and AMBER as well. Strong verbal communication with effective speaking and presentation skills resulting in many podium and poster presentations at Local and International Conferences. Please connect with me on LinkedIn or email me at s••••••••@gmail.com. I am ever willing to share my knowledge and know more about your interests as well. Also passionate about playing and watching soccer and basketball.
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