Sripathi Sureban

About Sripathi Sureban

I am a passionate drug discovery scientist with over 20 years of experience in developing targeted therapies to treat life-threatening diseases, including cancer, hematological disorders, and ophthalmological conditions. I specialize in identifying and characterizing therapeutic targets and have successfully developed innovative drug products such as siRNAs, monoclonal antibodies, CAR-T therapies, D-peptides, and small molecule inhibitors to treat GI cancers. My expertise lies in advancing drug candidates from discovery through IND-enabling studies to First-in-Human (FIH) clinical trials, with a strong focus on preclinical Pharmacokinetic/Pharmacodynamic (PK/PD) analyses and FIH dose prediction. I am committed to bridging the gap between cutting-edge research and impactful clinical solutions that improve patient outcomes. In addition to my professional work, I am passionate about mentoring aspiring researchers and enjoy playing cricket in my free time.Publications:

Experience

1. Principal Pharmacometrics Scientist

   Regeneron

   Dec 2025 — Present · Tarrytown, NY, US

   Design and Conduct PMx Analyses: Lead the design and execution of quantitative and PMx analyses to support pre-IND program development strategies across multiple programs.• Author Regulatory Documentation: Develop and contribute PMx content for regulatory submissions, including Investigational Brochures and briefing documents for pre-IND, End-of-Phase2, and other global Health Authority meetings.• Health Authority Representation: Serve as the PMx representative in key regulatory meetings, including pre-IND, Type C, pre-BLA, and other interactions with global Health Authorities.• Process Improvement Leadership: Contribute to or lead technical working groups focused on process improvement initiatives, development of new/revised SOPs, and cross-functional workstreams.• Scientific Publications: Publish research findings and analyses in scientific literature, including manuscripts and white papers, to advance the field and share insights.

Education

• St. John's College of Pharmacy

  Bachelor of Pharmacy (BPharm), Pharmacy

  1993 — 1997

• Government College of Pharmacy

  Master of Pharmacy (M. Pharm), Natural Products Chemistry and Pharmacognosy

  1997 — 1999

• PES University

  Associate's Degree, Diploma in Pharmacy

  1991 — 1993

• University of Madras

  Doctor of Philosophy (Ph.D.), Medical Microbiology and Pharmacognosy

  1999 — 2004

Skills

• Cell
• Transfection
• Microscopy
• Protein Expression
• Immunology
• Micro Array
• Reverse Transcription Polymerase Chain Reaction (Rt-Pcr)
• Biochemistry
• Ribosome Isolation
• Luciferase-Based Assays (Promoter and 3’utr Regulation Studies)
• In Vivo
• Rt-Pcr
• Protein Chemistry
• Immunohistochemistry
• Qpcr
• Nuclear and Cytoplasmic Shuttling of Proteins Identification -Heterokaryon Assay
• Primer Design, Pcr, Cloning, and Real-Time Rtpcr
• Immunoprecipitation
• Molecular Biology
• Plasmids, Sirna, and Microrna Transfections
• Real-Time Polymerase Chain Reaction (Qpcr)
• In Vitro Transcription and Translation
• Western Blotting
• Polymerase Chain Reaction (Pcr)
• Pluripotency
• Molecular Cloning
• Animal Models
• Cell Biology
• Normal and Cancer Stem Cell Isolation Using Facs/Flow Cytometry
• Molecular Genetics
• Confocal Microscopy
• Epithelial-Mesenchyman Transition (Emt)
• Pcr
• In Vitro Culturing (Clonogenic Assays) of Stem Cells and Cancer Cell Lines
• Cell Culture
• Rna Stability Assays
• Nuclear and Cytoplasmic Protein Extractions
• Emsa