Srinivas Bandi

About Srinivas Bandi

Self-driven and productive scientist with extensive experience in Antibody discovery and Engineering, including novel formats and protein engineering • Extensive experience in different antibody formats such as mAbs, scFvs, Fabs, VHH, bispecifics (CD3), multispecifics, Fc-fusion and CAR-Ts • Highly skilled in antibody lead selection, engineering, and optimization, focusing on post-translational modifications, humanization, germline antibody usage, CDR affinity maturation (libraries), thermal stability, immunogenicity, and potency• Collaborated with AI/ML teams to predict thermal stability of scFvs/ best variant of UTRs (mRNA) • Good experience in Antibody expression, purification, and characterization of antibodies – Biacore/thermal stability, Tm & Tagg (DSF)/DLS/Flow Cytometry/ADCC/EC50• Strong technical background in NGS, including antibody library design, immunoglobulin repertoire analysis, and sequence analysis (Distributed Bio)• Robust experience in antibody discovery methods, such as transgenic animals, single B-cell cloning (automation), yeast display, Phage Display and NGS-based discovery• Led two portfolio projects from pre-portfolio through lead selection as team leader at J&J• Managed interns, undergraduates, vendors, research associates, and scientists • Authored four patents and published articles in prestigious journals• Proven track record of collaborating with cross-functional teams

Experience

1. Director

   Prellis Biologics

   Aug 2025 — Present

   Directed antibody engineering and optimization initiatives, focusing on bispecifics, multispecifics, and Fc fusions. • Led a team of seven professionals in protein expression and purification (Expi-293, Expi-CHO, AKTA, SEC, CEX, Tm & Tagg, AC-SINS, LC-MS)• Collaborated with cross-functional teams to enhance protein sciences capabilities, driving innovation in antibody-peptide fusions.

Education

• Goethe University Frankfurt

  Germany, Doctor of Philosophy Ph.D., Biochemistry

  2005 — 2010

• Acharya Nagarjuna University

  India, Bachelor’s Degree, Chemistry

  2000 — 2003

• University of Hyderabad

  India, Master’s Degree, Biochemistry

  2003 — 2005

Skills

• Powerpoint
• Monoclonal Antibodies
• Immunology
• Pbmc Isolation
• Microsoft Office
• Signal Transduction
• Leukemia
• Cell Culture
• Management
• Real-Time Polymerase Chain Reaction (Qpcr)
• Leadership
• Western Blotting
• Immunoprecipitation
• Cell Biology
• Antibodies
• Cell
• Protein Expression
• Rna Isolation
• Qpcr
• Protein Purification
• Flow Cytometry
• Elisa
• Site-Directed Mutagenesis
• Mouse Models
• Molecular Biology
• Expression Cloning
• Cancer
• Infectious Diseases
• Research
• Inflammation