Soumitra Ghosh

About Soumitra Ghosh

Accomplished Translational neuroscientist with 14 years of research experience across neuroscience, drug development and neuroimmunology. • In-vivo lead with expertise in RNAi, oligo, small and large molecule CNS therapeutics, Direct & Systemic CNS drug delivery, and Machine Learning driven digital pathology technology development. • Excellent scientific record depicted by a patent, published peer-review scientific articles, invited presentations and research awards. • 5 years of leadership experience in managing scientists, CROs, and cross-functional R&D teams to generate preclinical data from preclinical stage to late-stage drug development. • A problem solver with the ability to work under tight deadlines and prioritize organizational goals.

Experience

1. Translational Lead

   Genentech

   May 2021 — Present

   In-vivo Lead, Translational Neuroscience, Genentech, South San Francisco USA.(Dec 2020- present) • Preclinical Translational Lead for a novel RNAi therapeutic modality (undisclosed target & modality)/Oligo targeting Parkinson’s disease. Led the in-vivo team responsible for generating preclinical data (PK, PD, Safety-Tox, Pathology) to prioritize drug candidates. Designed, executed and managed in-vivo studies to generate all the early/ late-stage research data package. Developed novel transgenic disease mouse model to measure the efficacy of CNS targeted therapeutics in neurodegenerative diseases. Directly involved in strategy development, selection of lead candidates to advance them in the pipeline and design non-GLP/ GLP NHP safety and target engagement studies.(Potential IND filing data) • In-vivo Lead for systemic delivery of antibody conjugated and LNP therapeutics in the brain Antibody/Peptide conjugated Oligo/RNAi/LNP systemic delivery to brain LNP barcoding technology to evaluate the biodistribution of DNA barcodes in brain through systemic delivery • Biology Lead for development of Artificial Intelligence driven pathology analysis platform Project lead of a cross-functional team with AI scientists and ML engineers to develop a platform for automated analysis of dopaminergic neuronal loss in Parkinson’s models.(3 months’ data analysis reduced to one week) • In-vivo lead to explore immunotherapy in Parkinson’s Disease.(Ab and AAV gene delivery) • In-vivo lead for external Business Deals (start-ups & Biotech MNCs) to explore delivery technology • Preclinical in-vivo biomarker development to examine disease efficacy for antibody therapy (undisclosed target) in Alzheimer’s disease.(IND filing data-package)

Education

• University of California, San Francisco

  Postdoc

  2016 — 2019

• Purdue University

  Doctor of Philosophy (Ph.D.), Integrative Neuroscience, Medicinal Chemistry and Molecular Pharmacology

  2009 — 2015

• SRM University

  Bachelor of Technology (B.Tech.), Genetic Engineering

  2005 — 2009