Sosthene Essono

Senior Scientist, Protein Engineering @Immunomic Therapeutics, Inc

Rockville, MD, US

Senior Scientist, Protein Engineering, Team Leader• Lead protein engineer of antibody development efforts in the design of advanced next-generation biopharmaceuticals including management of CRO advanced antibody library screening and novel proprietary sequence development.• Lead recombinant protein production both in-house and utilizing CRO’s.• Engineering design of antibody and recombinant protein structures and protein sequences for evaluation in robust manufacturable mammalian expression systems.• Responsible for molecular biology and vector construction including cell line construction for screening of design molecules.• Work as a team with discovery research teams to characterize target specificity and activity of lead molecules with cell binding and cell signaling assays using flow cytometry and other in-vitro technologies.• Assess recombinant protein quality attributes and manufacturability: such as stability, purity, heterogeneity, and activity through assays including cGE, cIEF, analytical SE, IEX, RP HPLC/UPLC), MALS, direct binding (Affinity and binding kinetics characterization) of lead molecules.• Protein modeling including structural analysis and protein: protein docking.• Design and execute experiments, analyze data, and troubleshoot methods.• Coordinate with cross-functional teams on the biological characterization of designed molecules; build consensus around candidates and take a leadership role in data-driven decision-making through the assessment of data and evaluation of results.

Université de Technologie de Compiègne (UTC)

Master's degree