Songjun Xiao
Bioorganic chemist interested in oligonucleotide chemistry, soft/biomedical materials, bioconjugation and delivery systems
- Role
- Process Development Senior Scientist at Axolabs
- Location
- Petaluma, CA, US
- LinkedIn followers
- 500 followers
About Songjun Xiao
Passionate and self-disciplined bioorganic chemist interested in DNA/RNA chemistry and…
Experience
Process Development Senior Scientist
Oct 2022 — Present · Petaluma, CA, US
Oligonucleotide synthesis on the μmol to mmol scale using AKTA OligoPilot, including single guide RNAs (sgRNA), aptamers and antisense oligos (ASO) containing modifications such as 2’-F, 2’-OMe, GalNAc etc.• Optimized sgRNA desilylation reactions for easier and safer manufacturing at large scale while reducing organic solvent usage• Purification of oligos using reverse-phase and ion-exchange chromatography• Identification and characterization of oligonucleotide impurities from IPRP-HPLC chromatograms• Routine oligo handling including cleavage/deprotection, conjugation, hybridization, desalting and lyophilization
Education
University of Utah
Postdoc
Nankai University
Bachelor of Science - BS
2010 — 2014
University of Maryland College Park
Doctor of Philosophy - PhD
2014 — 2019
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