Sita Patel
Bioinformatician | Python, R, NGS, Machine Learning | Genomics, Data Analysis | Cloud, Linux | Nextflow
- Role
- Senior Research Associate - Bioinformatics at Stratus Therapeutics
- Location
- Boston, MA, US
- LinkedIn followers
- 500 followers
About Sita Patel
Bioinformatics professional with experience in NGS pipeline preprocessing and analysis…
Experience
Senior Research Associate - Bioinformatics
Aug 2024 — Present · Boston, MA, US
Developing and validating in-house CRISPR genome-integrity pipelines and performing multi-omics analyses to characterize iPSC-derived hematopoietic stem cells (HSCs), driving automation, accuracy, and regulatory readiness of genomic data workflows.Highlights: • Built and validated in-house On-Target and Off-Target CRISPR pipelines using amplicon-seq data on AWS EC2, achieving analytical equivalence to vendor workflows. • Transitioned key analyses from vendor to internal control, reducing vendor dependency by >70% and improving turnaround time and cost efficiency. • Performed single-cell and bulk RNA-seq analyses to define transcriptional programs and validate HSC identity, integrating Seurat-based clustering and GSEA. • Conducted HLA population frequency analysis across global datasets (NMDP, IPD-IMGT, AFND) to guide genotype-driven donor selection for HSC production.Maintained validated pipelines for WGS, Oncopanel, and Optical Genome Mapping (OGM) assays; authored SOPs and report templates to align with QA and regulatory standards.
Education
Northeastern University College of Science
Master's degree
University of Mumbai
Bachelor of Pharmacy
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