Sirin Bano Mirza

About Sirin Bano Mirza

Passionate cell and molecular biology researcher with experience across leading…

Experience

1. Research Associate Scientist Corneal Regeneration & Nanotherapeutics Division

   Pandorum Technologies

   Feb 2024 — Present · Bengaluru, IN

   Contributed into exosome-derived therapeutics, contributing to the development of stem cell-based interventions for degenerative ocular conditions.• Developed sutureless corneal implants, reducing surgical time and addressing donor tissue shortages in preclinical evaluations.• Played a pivotal role in the preclinical development of KuragenX, facilitating collaborations with 3 major clinical research institutions.• Optimized 2D culture systems for mesenchymal stem cells (MSCs), supporting scalable expansion protocols for clinical-grade cell therapy production.• Achieved >95% purity in MSC-derived exosome isolation using ultracentrifugation and size exclusion chromatography (SEC), with downstream characterization via BCA, ELISA, and Western blotting.• Designed and validated functional assays (e.g, scratch/wound healing, fibrosis models) to assess therapeutic properties such as anti-inflammatory and pro-migratory effects of exosomes.• Improved exosome production workflows, resulting in a 3-fold increase in yield and enhanced consistency of cargo profiles (miRNA, mRNA, protein).• Contributed to the development of tissue-specific regenerative exosomes, targeting corneal repair via conditioned culture systems and efficacy testing.• Generated critical preclinical datasets to support the advancement of corneal epithelial repair therapeutics.

Education

• S.S. Jain Subodh PG (Autonomous) College, Jaipur

  MSc in Cell Biology, Research and Development Management

• Navjeevan Science School, Sikar

  Bachelor of Applied Science - BASc, Zoology/Animal Biology