Simran Padhye
Drug Discovery Scientist | Gene Editing | Assay Development & High-Throughput Screening
- Role
- Senior Associate Scientist Ii at Prime Medicine, Inc.
- Location
- Cambridge, MA, US
- LinkedIn followers
- 500 followers
About Simran Padhye
Scientist with 6+ years building and leading bioassay programs across gene editing, RNA therapeutics, and small molecule drug discovery — spanning Prime Medicine, Eloxx Pharmaceuticals, Skyhawk Therapeutics, and Cygnal Therapeutics in the Boston biotech corridor.At Prime Medicine, I serve as Screening Lead across heme, lung, and liver indications, owning assay development, qualification, and end-to-end campaign execution using primary human cells (PHH, HSCs, bronchial epithelial), NHP-derived samples, and LNP delivery platforms. I partner directly with PK/PD, NGS, disease and informatics teams to translate in vitro data into in vivo decisions — and build the scalable workflows and automated pipelines that keep multi-target programs moving. My technical foundation spans cell-based functional assays, translational pharmacology, primary cell handling, qPCR, ELISA, and automation platforms (Tecan Fluent, D300). I\'m drawn to programs where precision delivery and biological programmability intersect — and to teams that move fast without cutting corners on data quality.
Experience
Senior Associate Scientist Ii
Jul 2024 — Present · Cambridge, MA, US
Led cross-functional screening strategies for blood, liver, and lung programs, aligning internal teams and external partners (BMS, CFF) to shape therapeutic nomination pathways- Coordinated with PK/PD and in vivo teams to design in vitro studies that informed dosing and formulation decisions; delivered preclinical-to-clinical correlation data packages for GSD1b and ATP7b- Developed automated data pipelines and standardized workflows, enhancing throughput, reproducibility, and knowledge transfer across the company- Directed multi-target primary cell screening to expand translational relevance and model diversity- Initiated and led a platform-wide reproducibility and performance standardization initiative.
Education
Northeastern University
Master's degree, Pharmaceutical Sciences
2019 — 2021
Thadomal Shahani Engineering College 32nd Road TPS III Bandra Mumbai 400 050
Bachelor of Engineering, Biotechnology
2015 — 2019
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