Simon P. Chandler

About Simon P. Chandler

In addition to leading clinical research in gene therapy, biologics and small molecules as therapies for ophthalmic and systemic indications, I also form a bridge between academic and industrial research; lecturing in US-based clinical development for both academic and corporate teams in the US and the EU. I leverage my experience and expertise in molecular biology, clinical development and regulatory interaction to maximize performance in cross-functional teams on both sides of the Atlantic Ocean. My skill set, particularly in bringing European and Asiatic developmental opportunities to the US helps enhance pipeline strength and develop a solid trust-based Company culture on the international stage. Specifically, I have experience in FDA and ICH-driven drug development from preclinical/non-clinical studies through all Phases of clinical trial design in small molecules, biologics and gene therapies. I have proven success and expertise in study design; adaptive, placebo-controlled and combinatorial approaches, as well as protocol development for Retinal disease, Rare and Orphan disorders, Glaucoma, Dry Eye, Allergy, Anti-infectives and Cataract-IOL implantation in refractive surgery. In addition I have designed trials in peripheral arterial disease, diabetic neuropathy and numerous retrospective cause-and-effect analyses.I specialize in re-purposing and strengthening the Company pipeline through knowledge of mechanism-based molecular signalling cascades and cellular/nuclear response. I encourage the translational linking and utilising of the research and development expertise within the Company and within my network for evaluation of in-licence opportunities as well as existing pipeline life-cycle management.

Experience

1. VP and Head of Ophthalmology

   Channel Therapeutics

   Jan 2023 — Present

   Channel Therapeutics is dedicated toward developing non-opioid analgesics for the treatment of acute and chronic pain indications.I head the ophthalmology section where we are developing formulations for the treatment of ocular pain both preclinically and in the clinic.

Education

• University of Southampton

  Ph.D., Molecular Biology

• University of Portsmouth

  B.Sc, Molecular Biology

Skills

• Pharmaceutical Industry
• Fda
• Life Sciences
• Clinical Trials
• Clinical Development
• Medical Affairs
• Process Improvement
• Pharmaceutics
• Drug Discovery
• Medical Devices
• Clinical Research
• Cell
• Biotechnology
• Research and Development (R&D)
• U.s. Food and Drug Administration (Fda)
• Molecular Biology
• Translational Research
• Regulatory Affairs
• Lifesciences
• Orthopedic
• CRO Management
• Ctms
• Cross-Functional Team Leadership
• Drug Development
• Gcp
• Oncology
• Urology
• Protocol
• Biomedical Engineering
• Ind
• Asthma
• Clinical Study Design
• Gxp
• Regulatory Submissions
• R&D
• Ophthalmology