Shu-Hao Liou

About Shu-Hao Liou

Innovative and impact-driven protein engineering scientist with 8+ years of experience leading therapeutic protein discovery and vector design across academia and biotech setting. Demonstrated success in advancing programs from early discovery to IND-enabling stages, with a strong track record in rational biological design, structural elucidation, and cross-functional leadership. Proven leadership in cross-functional teams and collaborations with CROs to advance therapeutics programs from design to in vivo studies. Passionate and experienced in science, drug discovery, manufactory, human management, and leadership.

Experience

1. Senior Scientist

   Bristol-Myers Squibb

   Nov 2025 — Present · Devens, MA, US

   Lead downstream process support for commercial manufacturing and technology transfer activities, including mAbs, BITEs, fusion proteins.2. Provide technical input for process investigations, including root cause analysis and implementation of corrective and preventive actions (CAPAs).3. Drive continuous improvement initiatives to enhance process robustness, efficiency, and compliance.4. Support downstream activities for technology transfer, process validation, and preparation of Chemistry, Manufacturing, and Controls (CMC) documentation.5. Contribute to regulatory filings and interface with regulatory agencies, including support for inspections and responses to inquiries.6. Design and execute technical studies to support manufacturing investigations or technology transfer of new processes. This includes leveraging laboratory and scale-down models for Protein chromatography, Viral inactivation, Viral filtration, Ultrafiltration/diafiltration, Membrane filtration, Depth filtration, Centrifugation.7. Document and verify experimental data, interpret results in alignment with lab protocols and manufacturing processes, and generate comprehensive technical reports.8. Collaborate effectively with partners across MS & T, Manufacturing, Process Development, Quality, and Regulatory to align on technical strategies and execution.9. Evaluate emerging downstream process technologies and recommend improvements as appropriate.

Education

• University of California, Davis

  Doctor of Philosophy (Ph.D.), Biophysics

  2011 — 2016

• National Cheng Kung University

  Master of Science (MS), Physics

  2007 — 2009

• National Cheng Kung University

  Bachelor of Science (B.S.), Physics

  2003 — 2007