Shivangi Srivastava
Senior Scientist @Bristol Myers Squibb
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WORK HISTORY
Senior Scientist @Bristol Myers Squibb
Lawrenceville, NJ, US
Designed and executed phenotypic HTS to identify novel small molecule hits in oncology and immunology.Performed MoA studies integrating pathway analysis, imaging, and CRISPR perturbations to establish mechanistic hypotheses.Developed 3D spheroid, co-culture, and primary cell models to enable lead optimization and enhance predictive validity.Advanced multiple oncology programs from hit triage to lead optimization and candidate nomination.Collaborated with Chemistry, DMPK, Structural Biology, and Computational teams to evaluate chemical series and guide design cycles.Mentored junior scientists and led scientific discussions to shape experimental strategy and dataset interpretation.Presented program data and recommendations at governance and cross-functional decision forums.
EDUCATION
Daulat Ram College
Bachelor's Degree
University of Houston
Doctor of Philosophy (Ph.D.)
Goa University
Master's Degree
ABOUT SHIVANGI SRIVASTAVA
I am a Senior Scientist in Oncology Drug Discovery with expertise in phenotypic screening (HTS), mechanism-of-action studies, and complex cellular model development to advance small molecule programs from hit identification through lead optimization and clinical candidate nomination.My work centers on building and applying translationally relevant cell systems—including 3D spheroids, tumor co-cultures, primary cell systems, and CRISPR perturbation models—to uncover disease mechanisms and guide medicinal chemistry. I integrate in-vitro assays including cellular signaling, metabolism, pathway biology and imaging to define actionable biological hypotheses and drive strategic decision-making in discovery teams.Core Strengths:Complex assay design to improve translatability early in discoveryMechanism-of-action elucidation and target deconvolutionCRISPR functional genomics and synthetic vulnerability mappingCross-functional leadership across Biology, Chemistry, Structural Biology, and Computational teamsClear communication of biological insights to influence program strategyI am driven by scientific curiosity, elucidating mechanisms, and the belief that translationally relevant cellular assays accelerate drug discovery and increases the chances of success.
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