Shiva Kumar Shanmukhappa
Senior Director Senior Research Fellow @Vertex Pharmaceuticals
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WORK HISTORY
Senior Director Senior Research Fellow @Vertex Pharmaceuticals
My role includes providing strategic and scientific leadership in the design, conduct and interpretation of pathology endpoints for animal model development, target identification/validation, and in vivo pharmacology and nonclinical biomarker development studies including the use of cutting-edge molecular diagnostic and digital imaging technologies as part of discovery & investigative pathology groupProvide anatomic pathology evaluation of investigative pathology and regulatory toxicity studies from lead identification/optimization through registration and post-marketing including peer review of outsourced nonGLP and GLP toxicology studies.Expert scientific leadership in discovery, translational research, and regulatory nonclinical safety profiling activities as a key partner on cross-functional teams within Vertex, working with a high-functioning multidisciplinary team of preclinical safety and biomarker scientists including a Board-certified veterinary clinical pathologist and an extensive network of external consultants and contract research organizationsParticipation in regulatory submission document preparation, poster presentations and scientific publications, including addressing queries from global health authorities
EDUCATION
Kansas State University
Doctor of Philosophy (PhD), Veterinary Pathology and Pathobiology
Veterinary College, Uninversity of Agricultural Sciences, Bangalore
Bachelor of Veterinary Science, Veterinary Pathology and Pathobiology
Harvard Medical School
Comparative Veterianry Pathology
Sainik School, Bijapur
High School Diploma, General Studies
Indian Veterinary Research Institure, Bareily, UP
Master's degree, Veterinary Virology & Immunology
SKILLS
ABOUT SHIVA KUMAR SHANMUKHAPPA
As Comparative Veterinary Pathologist, I have extensive experience in interpretation of varied animal models of human diseases. Some of the disease models that I have worked include Sickle Cell Disease, Renal diseases, NASH, NAFLD, HIV/AIDS, Biliary Atresia, Primary Biliary Cirrhosis, Liver Fibrosis, Idiopathic Pulmonary Fibrosis, Rheumatoid Arthritis, Cohn’s and Ulcerative Colitis. Majority of my collaborative research pathology experience has resulted in publications, presentations & grants. I also have considerable experience in evaluation of mouse embryos in a setting of toxicity as well as phenotypic characterization of genetically modified mouse. In addition to mouse, I have also experience evaluating rhesus macaque, zebra fish and Xenopus tissues in context of human disease models. I have also experience evaluating safety and toxicology of stem cells therapy, gene therapy as well new drug therapy prior to FDA IND submission. In addition, I perform image analysis for researchers for cell count, fibrosis evaluation, colocalization using image J as well as Aperio Image scope systems. As a researcher, I have vast first-hand experience in performing hypothesis driven research. Some of the research areas I have worked include viral pathogenesis, virus-host interactions, liver repair and regeneration, stem cell induction, Liver fibrosis, Non-alcoholic fatty liver disease (NAFLD), Non-alcoholic steatohepatitis (NASH), as well as metabolic complications of HIV all of which have resulted in publications and presentations.
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