Shibu John
Clinical Bioinformatician @Nonacus
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WORK HISTORY
Clinical Bioinformatician @Nonacus
Birmingham, GB
Leading end-to-end bioinformatics pipeline development for a CE-IVDR ctDNA diagnostic platform covering bladder cancer liquid biopsy and hereditary cancer panels- Architected and implemented the full AVITI sequencer bioinformatics pipeline, including automated S3 data discovery and workflow launches via the Seqera Platform API- Developed Python automation for samplesheet generation and pipeline orchestration across Illumina and AVITI platforms, cutting manual preparation time by ~70% per sequencing run- Led the IVDR validation study for the bladder cancer ctDNA panel, including limit of detection analysis and formal report authorship- Built clinical variant export tooling integrating with QCI, with a browser-based interface for clinical scientists- Acted as technical interface between bioinformatics and clinical teams, guiding QC decisions and reporting workflows
EDUCATION
Bharathiar University
Master of Science - MSc, Bioinformatics
Bharathiar University
Bachelor of Science (B.Sc.), Mathematics and Computer Science
SKILLS
ABOUT SHIBU JOHN
Principal clinical bioinformatician with 20 years\' experience across NHS diagnostics, Illumina, and clinical genomics. My work centres on building and maintaining NGS pipelines that actually work in production - from liquid biopsy and WGS analysis to automated reporting workflows and cloud infrastructure. I\'ve spent most of my career in regulated environments where the pipelines have to be right, not just functional. That means ISO 15189, IVDR validation, UKAS audits, and clinical variant interpretation alongside the technical work. On the technical side, I work mainly in Python, R, and Bash, with Nextflow, AWS, and DRAGEN making up the core stack. I\'m at my best when the problem sits at the intersection of bioinformatics, clinical science, and engineering. Most recently I\'ve been leading the build of end-to-end AVITI sequencer integration and automating Seqera-based pipeline launches at Nonacus.
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