Sheo Singh

About Sheo Singh

Over 30 years of drug discovery and development experience (24 years at Merck) from bench to leadership position with increasing responsibilities covering wide therapeutic areas including strategies for program executions- anticancer, cardiovascular, hypertension, anthelmintic, antiparasitic, coccidiostat, antimalarial, immunoregulant, anti-diabetics, antiviral including HIV- with last ten years concentrating in the discovery and development of antibiotics to treat bacterial resistant infections. Discovered platensimycin and platencin as FAS inhibitor and rationally correlated liver specific FAS inhibition with glucose lowering and repurposed platensimycin as antidiabetic agent; discovered kibdelomycin and thiazomycin(s) as oral Clostridium difficle agents. Over twenty years project leadership and management experience that include leading and managing multiple projects simultaneously. Extensive experience (over 10 years membership of Merck\'s anti-infective research licensing committee) in in- and out-licensing strategy, due diligence and technology transfer activities. Functional experiences include medicinal and natural products chemistry, analytical chemistry, de novo structure elucidation, complex purification, and virtual drug discovery and development, CRO and partner management. Oversaw, discovered and/or contributed to the discovery of more than nine preclinical development candidates including antibiotic/antifungal/antiparasitic agents, and represented a few in Early Development Teams. A natural product lead from these discoveries led to an analog, which was conjugated with an ADC to an FDA approved drug, brentuximab vedotin (ADCETRIS(TM)). Two products, OXI4503 and ZYBRESTAT(TM), are in phase human trials for treatment of cancer.

Experience

1. Fellow

   Drew University

   Nov 2023 — Present · Madison, NJ, US

Education

• Arizona State University

  Postdoctoral Fellow, Natural Products and Medicinal Chemistry

  1983 — 1984

• Deendayal Upadhyay Gorakhpur University

  Master of Science (MS), Organic Chemistry

  1975 — 1977

• University of Glasgow

  Postdoctoral Fellow, Organic Synthesis/Biosynthesis

  1982 — 1983

• Deendayal Upadhyay Gorakhpur University

  Bachelor of Science (BS), Chemistry/Botany/Zoology

  1973 — 1975

• Avadh University, Faizabad/Central Institute of Medicinal & Aromatic Plants, Lucknow

  Doctor of Philosophy (PhD), Natural Products Chemistry

  1977 — 1981

Skills

• Clinical Development
• Molecular Biology
• Antifungal Drug Discovery and Development
• Team Leadership
• Biotechnology
• Structure Elucidation
• Chemistry
• Drug Development
• Biopharmaceuticals
• Complex Purifications
• Nmr
• Medicinal Chemistry
• Biochemistry
• Program Management
• Goal-Oriented Individual with Strong Leadership Capabilities
• Antibacterial Drug Discovery and Development
• Pharmaceutical Industry
• Operational Efficiency
• Creative Problem Solving
• Collaboration
• Glp
• Drug Discovery
• Natural Products
• Project Management
• Hplc
• Fermentation Technology
• Oncology
• Building Relationships
• Organic Chemistry
• CRO
• Nmr Spectroscopy
• Virtual Drug Discovery
• Life Sciences
• Lifesciences
• Cross-Functional Team Leadership
• Strongly Self-Motivated
• Pharmacology
• Biotransformation
• Analytical Chemistry
• Chromatography