Shae Padrick

About Shae Padrick

The eukaryotic cytoskeleton is a fascinating collection of proteins and regulatory factors that allow cells to dynamically control their movement, cell division, cell-cell interactions. These filamentous protein systems also enable the intracellular movement and organization of organelles, vesicles and RNA granules. These essential processes are corrupted during numerous diseases including cancer metastasis and pathogenic infection. A fascinating feature of this system is that many of the rearrangements happen too quickly to be accounted for by transcriptional changes, indicating that most of the chemical logic happens through changes in protein-protein interactions. I believe that this complex system is fundamentally knowable. I am interested in discovering the molecular rules that govern fundamental cytoskeletal rearrangements, higher-order cytoskeletal assembly and how these rules are altered by diseases. I am applying our considerable fundamental knowledge in the discovery of novel therapeutics and therapeutic strategies. To accomplish those goals, I bring a comprehensive toolset that includes reconstitution biochemistry, quantitative measurement, imaging, protein engineering, structural biology, bioinformatics and kinetic modeling at multiple length scales.

Experience

1. Senior Research Scientist

   Brandeis University

   Jul 2025 — Present · Waltham, MA, US

   At Brandeis University, I am engaged in advanced research on the control of dynamic rearrangements of the eukaryotic cytoskeleton. My work focuses on the biochemical and structural interactions of actin with septins, microtubules, and intermediate filaments, contributing to significant advancements in our understanding of cytoskeletal organization.

Education

• University of California, Berkeley

  Bachelor's Degree, Biochemistry and Molecular Biology

  1994 — 1998

• Yale University

  Doctor of Philosophy (Ph.D.), Biochemistry, Biophysics and Molecular Biology

  1998 — 2003

Skills

• Cell
• Molecular Biology
• Fluorescence Microscopy
• Fluorescence Based Assays
• Protein Engineering
• Life Sciences
• Kinetic Modeling
• Structural Biology
• Protein Purification
• Microscopy
• Molecular Cloning
• Science
• Biochemistry
• Pcr
• Cell Culture
• X-Ray Crystallography
• Cell Biology
• Protein Expression
• Research
• Analytical Ultracentrifugation
• Protein Chemistry
• Biophysics
• Western Blotting