Severin Donald Kamdem

Senior Scientist, Genomics Technology Computational Biologist - Oncology @Pathos

Salt Lake City, UT, US

Designed and scaled a 384 high-throughput RNA-seq platform using 3D primary patient-derived tumor organoids and cell lines for drug screening and MoA discovery, boosting data quality by 40% and enabling profiling of over 50 compounds across diverse tumor models.• Developed and optimized a RNA-seq data analysis workflow (from demultiplexing, QC to DGE analysis), reducing turnaround time by 70%, increasing reproducibility by 50%, and significantly expanding lab-wide analytical throughput.• Conducted differential gene expression and pathway analyses to prioritize leads, guide MoA elucidation, and support drug development pipeline decisions.• Evaluated, and onboarded advanced omics platforms including SomaScan, Olink, scRNA-seq (10X Genomics, PARSE), spatial transcriptomics (NanoString, CosMx, GeoMx), enhancing multi-omics capabilities and supporting MoA for pipeline assets to support FDA submissions.

Catholic University of Central Africa, Cameroon

Bachelor (Hons)

3RI Technologies Pvt. Ltd.

Certificate

University of Cape Town

Doctor of Philosophy - PhD

University of Yaoundé I, Cameroon

Bachelor's degree

Catholic University of Central Africa, Cameroon

Master's degree