Severin Donald Kamdem
Research Scientist | Genomics | Inflammation | Fibrosis | Oncology | Drug Discovery | Computational Biology | Leadership | Volunteer.
- Role
- Senior Scientist, Genomics Technology Computational Biologist - Oncology at Pathos
- Location
- Salt Lake City, UT, US
- LinkedIn followers
- 500 followers
About Severin Donald Kamdem
I am a results-driven scientist with over 7 years of experience in functional genomics…
Experience
Senior Scientist, Genomics Technology Computational Biologist - Oncology
Sep 2024 — Present · Salt Lake City, UT, US
Designed and scaled a 384 high-throughput RNA-seq platform using 3D primary patient-derived tumor organoids and cell lines for drug screening and MoA discovery, boosting data quality by 40% and enabling profiling of over 50 compounds across diverse tumor models.• Developed and optimized a RNA-seq data analysis workflow (from demultiplexing, QC to DGE analysis), reducing turnaround time by 70%, increasing reproducibility by 50%, and significantly expanding lab-wide analytical throughput.• Conducted differential gene expression and pathway analyses to prioritize leads, guide MoA elucidation, and support drug development pipeline decisions.• Evaluated, and onboarded advanced omics platforms including SomaScan, Olink, scRNA-seq (10X Genomics, PARSE), spatial transcriptomics (NanoString, CosMx, GeoMx), enhancing multi-omics capabilities and supporting MoA for pipeline assets to support FDA submissions.
Education
Catholic University of Central Africa, Cameroon
Bachelor (Hons)
2010 — 2011
3RI Technologies Pvt. Ltd.
Certificate
2021 — 2022
University of Cape Town
Doctor of Philosophy - PhD
2018 — 2020
University of Yaoundé I, Cameroon
Bachelor's degree
2007 — 2010
Catholic University of Central Africa, Cameroon
Master's degree
2011 — 2014
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