Santhosh Karanth

Investigator Senior Scientist @Scribe Therapeutics

Alameda, CA, US

Spearheaded biology strategy for therapeutic programs, driving biomarker development, assay development, and mechanism-of-action (MOA) studies to advance candidate selection.Led cross-functional collaboration with platform engineering, computational biology, and in vivo teams to optimize on-target activity, minimize off-target effects, and prioritize lead candidates.Developed and validated high-throughput screening (HTS) assays in primary hepatocytes and immortalized cell lines for potency estimation (EC50/EC90), MOA studies, and off-target validation.Established biomarker strategies and executed assay validations for cell and tissue analysis, including:Protein-level: ELISAs, Jess-Western BlotNucleic acid-level: qRT-PCR, ddPCR, genome edit detectionAuthored SOPs for regulatory compliance and created Benchling ELN records for drug substances and experimental data, ensuring full traceability and audit readiness.Designed and managed animal studies to establish PK/PD relationships and efficacy, directly supporting lead candidate selection.Presented key findings to cross-functional teams, leadership, and external stakeholders, influencing strategic decisions and enhancing company visibility.

Dalhousie University

PhD