Samantha Desmarais
Bioprocess Applications Senior Engineer | Downstream Process Development | AAV Purification | Gene Therapy | Proteins | Non-viral GT | Chromatography | Principal Scientist
- Role
- Bioprocess Applications Senior Engineer at MilliporeSigma
- Location
- Boston, MA, US
- LinkedIn followers
- 500 followers
About Samantha Desmarais
I am a Downstream Process development scientist focusing on AAV gene therapies. I have over a decade of experience advancing purification technologies as a subject matter expert in chromatography. My expertise is applicable to biologics, as I have a PhD in protein biochemistry, and my experience and knowledge with downstream AAV processing is highly transferrable to proteins and non-viral gene therapy. I\'m excited to combine my purification knowledge with my passion for working directly with scientists, promoting innovative technologies. Key Skills: downstream process development, liquid chromatography (FPLC, UPLC, HPLC including affinity, IEX, SEC, RP-IP, multi-modal, HIC), mass spectrometry (LC-MS, GC-MS), electrophoresis (capillary, microchip, slab), protein expression, protein purification
Experience
Bioprocess Applications Senior Engineer
Jan 2026 — Present · Bedford, MA, US
Work within the Single Use and Integrated Systems Downstream Applications R&D team to develop innovative products for the processing and purification of biopharmaceutical and biotech product streams
Education
Trinity College-Hartford
BA, Chemistry, French
Dartmouth College
PhD, Chemistry
Skills
- Capillary Electrophoresis
- Primer Design
- Protein Assays
- Cytoskeleton
- Light Scattering
- High Throughput Screening
- Biophysical Chemistry
- Morphology
- Biomems
- Chemistry
- Microfabrication
- Analytical Biochemistry
- Dna Quantification
- Structural Biology
- Pathogenesis
- Immunofluorescence
- Liquid Chromatography
- Protein Crystallization
- Microfluidic Devices
- Protein Purification
- Pcr
- Analytical Chemistry
- Laboratory
- Molecular Biology
- Fluorescence Microscopy
- Bacterial Cell Culture
- Western Blotting
- Hybridization
- Drug Metabolism
- Polymer Chemistry
- Pharmacology
- Fplc
- Uplc/Hplc
- Fluorescence Spectroscopy
- Dna Sequencing
- Peptides
- Protein Expression
- Microscopy
- Immunology
- Microfluidics
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