Saikat Manna
mRNA formulation & Delivery, LNP formulation, Lipid Synthesis, Targeted Delivery, Vaccines, Gene Therapy, Let’s Connect!
- Role
- Senior Scientist Manager, Delivery & Formulation - Mrna Center of Excellence at Sanofi
- Location
- Boston, MA, US
- LinkedIn followers
- 500 followers
About Saikat Manna
An innovation driven scientist with a demonstrated history of working on nanoformulation development for mRNA/subunit vaccines, genomic medicines & cancer immunotherapy. Expert in mRNA formulation development, lipid synthesis, targeted delivery of therapeutics, nano-delivery techniques, bioconjugation techniques, analytical characterization & process optimization.
Experience
Senior Scientist Manager, Delivery & Formulation - Mrna Center of Excellence
Jan 2023 — Present · Waltham, MA, US
Developed a novel LNP platform technology with enhanced efficacy in vaccines and gene therapy with low reactogenicity.• Transitioned early stage technology from concept to clinic within 2.5 years.• Led the effort on development of LNP platform to enhance efficacy of liver-targeted gene therapy programs from pre-clinical concept to NHP studies.• Optimized LNP formulations for passive targeting and active ligand-based targeting to specific tissues and cells.• Optimized formulations for alternative routes of administration. Improved formulation efficacy from 0% to 100% survival in vaccination challenge studies• Experienced in large-scale process development for LNP formulations.• Represented the team in research platform core strategy meetings to communicate updates for decision making.• Managed direct reports on various projects. • Communicated with CROs and external partners.• Submitted two invention disclosures.
Education
Arizona State University
Doctor of Philosophy - PhD, Chemistry
2010 — 2016
Calcutta University, Kolkata
Bachelor of Science - BS, Chemistry (Major)
2005 — 2008
Indian Institute of Technology, Kharagpur
Master of Science - MS, Chemistry
2008 — 2010
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