Sai Giridhar Sarma K.

WORK HISTORY

EDUCATION

SKILLS

ABOUT SAI GIRIDHAR SARMA K.

Highly self-driven synthetic chemist with 9+ yrs.(Post Ph.D.) of experience across Industry and Academia with proven ability to lead and execute process chemistry & small molecule pre-clinical drug discovery projects (oncology and inflammation) resulting in 7 publications, 1 granted patent and 1 PCT publication. Skilled in route scouting, proposing non-infringing route of synthesis, synthesizing lead molecules/drug candidates and advanced intermediates on a diverse scale (mg to g to kg), developing and optimizing the process for the synthesis of small molecules on a large scale in compliance with ICH guidelines, Impurity profiling of APIs, tech transfer, formulating SOPs, raw material qualification and route selection document. Broad understanding of the fundamental principles of organic synthesis, drug discovery/development with demonstrated abilities to design new drug leads, optimize lead molecules with drug like properties and safety profile. Proficient in solving challenging synthetic problems, comprehending critical information from biological research literature and drawing conclusions based on rigorous data analysis. Excellent interpersonal, oral and written communication skill with the ability to understand, interpret, and present the scientific data in research conferences/meetings.Specialties: Structure based drug design, Hit to Lead (H2L), Lead optimization, library synthesis, high throughput chemistry, Process R&D, Scale up, Organic Synthesis (10 mg to >200 g scale), Kilogram synthesis, Adherent cell culture, Protein Expression and purification, In-vitro cytotoxicity and biophysical assays.