Rudy Gregory Jacquet

Postdoctoral scientist: Cell-Based Phenotypic Screening

Role
Assoc Scientist, Post Doc Fellow at Merck
Location
Jersey City, NJ, US
LinkedIn followers
500 followers

About Rudy Gregory Jacquet

Neuroscientist with a Ph.D. from Weill Cornell Medicine and industry experience at Merck,…

Experience

  1. Assoc Scientist, Post Doc Fellow

    Merck

    Jan 2024 — Present · Rahway, NJ, US

    Conducted high-throughput, target-based screening to identify small molecules that modulate actin polymerization in human macrophages exposed to amyloid beta aggregates and discovered compounds that modulate the PLC/PKC signaling pathway- Assessed actin polymerization in M0, M1, M2 macrophages using a 384-well image-based assay and identified M1 macrophages as the most responsive to amyloid beta aggregates- Established a phenotypic genomic screen involving CRISPR and Cell painting to investigate the impact of Alzheimer’s disease-associated genes on myeloid cell responses to amyloid-beta species (oligos, fibrils, plaques)- Applied AI/ML techniques (Random Forest, K-Means, Hierarchical clustering, Similarity score) to analyze image-based, high-dimensional data to identify effects of small molecule and genomic perturbations- Delivered scientific presentations through a TED-style talk and poster sessions at the Merck Technology Symposium- Coordinated monthly Postdoc seminar, organizing speakers, and managing event logistics to promote knowledge sharing and collaboration.

Education

  • Weill Cornell Graduate School of Medical Sciences

    Doctor of Philosophy - PhD

    2016 — 2023

  • NYU Tandon School of Engineering

    Master's Degree

    2012 — 2014

  • City University of New York-Herbert H. Lehman College

    Bachelor's Degree

    2005 — 2010

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Rudy Gregory Jacquet — Assoc Scientist, Post Doc Fellow at Merck in Jersey City, NJ, US | Unifers