Rhishikesh Thakare

About Rhishikesh Thakare

I’m an ADME/DMPK leader with cross-modality experience in small molecules and biologics, focused on turning complex pharmacokinetic and metabolism questions into clear, actionable program decisions. I lead modality appropriate mechanistic ADME, translational PK/PD, and risk mitigation strategies to enable candidate selection and support milestone decisions from discovery through IND/IMPD readiness.I partner with cross functional teams across discovery and development to identify attrition risks early, build practical mitigation plans, and deliver integrated data packages that guide candidate selection, study design, and portfolio choices—ensuring programs are positioned for critical go/no go milestones.I connect bioanalytical strategy, biomarker plans, translational PK/PD modeling, human PK prediction and dose projection, and—when applicable—immunogenicity risk assessment into decision ready packages, particularly as programs advance toward IND/IMPD.I also prepare ADME/clinical pharmacology content for IBs and regulatory submissions (IND/IMPD, NDA/BLA) and represent ADME in health authority interactions and responses to agency questions.Specialties: ADME/DMPK • PK/PD • PBPK • Human PK Prediction • Dose Projection • Regulatory Submissions (IND/IMPD/NDA/BLA) • Portfolio Decision Support • Multiparameter Optimization • Cross-functional Leadership

Experience

1. Director

   Eli Lilly and Company

   Jan 2026 — Present · Boston, MA, US

Education

• University of Nebraska Medical Center

  Doctor of Philosophy (PhD), Pharmaceutical Sciences

  2012 — 2017

• National Institute of Pharmaceutical Education and Research

  M.S. Pharm., Pharmaceutical Analysis

  2006 — 2008

• Sant Gadge Baba Amravati University, Amravati

  B.Pharm., Pharmacy

  2002 — 2006

Skills

• Pharmacokinetics
• Assay Development
• Hplc
• Dmpk
• High-Performance Liquid Chromatography (Hplc)
• Bioanalysis
• In Vitro
• Drug Metabolism
• Drug Delivery
• Drug Discovery