Rekha Pal
Preclinical Oncology | Drug Discovery | Precision Oncology | Translational Oncology
- Role
- Senior Director at Crown Bioscience
- Location
- Pittsburgh, PA, US
- LinkedIn followers
- 500 followers
About Rekha Pal
Extensively worked in translational cancer research using human patient’s blood plasma or serum and bone marrow sample for gene expression and co-related with clinical data for the targeted biomarker identification with the drug treatment. Identified molecular targets and mechanisms of action and drug resistance of thalidomide and its immunomodulatory derivatives (IMiDs, Celgene drug) including pomalidomide and lenalidomide (Pal R et all, Blood 2010, Li S, Pal R et all, Blood 20011) by using hematopoietic stem cell, myeloma cancer cell and patient bone marrow and peripheral blood mononuclear cells. Developed novel assays for the preclinical evaluation of drugs such as cell proliferation (MTT) or thymidine uptake, apoptosis (Annexin V) by flow cytometry and cell cycle analysis in primary human patient cell or human cell lines based cultures. Identification and preclinical development of small molecule therapeutics like diallyl trisulphide (DATS)- a natural garlic derivative. Maintenance, culture and differentiation of human and mouse embryonic stem cells and their targeting by lentiviral vectors to explore the self-renewal mechanism. Excellent writing ability as an Independent investigator and co-investigator resulting funded grants and high impact factor publications. Worked as a supervisory capacity, an individual contributor and in a team environment. Consultant for the Celgene Corporation for exploring the molecular mechanisms of actions of IMiDs in multiple myeloma. Resolved research and technical problems in various translational based projects associated with Immunomodulatory derivatives (IMiDs) and hematological malignancies.Specialties: A translational cancer researcher with special focus on translational development of novel immunomodulatory agents in hematological and solid malignancies, biology of stem cells, molecular oncology, cellular signaling, and biomarker identification.
Experience
Senior Director
Apr 2022 — Present · Pittsburgh, PA, US
Education
Central Drug Research Institute/ Kanpur University
PhD, 2003, Anti-estrogen and cancer
1997 — 2001
University of Pittsburgh
Post-Doctoral
Kanpur University
MSc, Endocrinology
Nagpur University
BSc, Microbiology
Skills
- Therapeutic Areas
- Pharmacology
- Cell Culture
- Protein Expression
- Apoptosis
- Stem Cells
- Endocrinology
- Immunology
- Assay Development
- In Vitro
- Molecular Biology
- Immunohistochemistry
- Qpcr
- Pcr
- Protein Chemistry
- Therapeutics
- Translational Research
- Immunofluorescence
- Cancer
- Biomarkers
- In Vivo
- Cell Biology
- Clinical Development
- Western Blotting
- Flow Cytometry
- Cell
- Transfection
- Hematology
- Cell Signaling
- Tissue Culture
- Confocal Microscopy
- Oncology
- Animal Models
- Science
- Biochemistry
- Drug Discovery
- Grants
- Elisa
- Cancer Research
- Cell Based Assays
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