Rajendra Khanal
Lnp Formulation Scientist @Merck KGaA, Darmstadt, Germany
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WORK HISTORY
Lnp Formulation Scientist @Merck KGaA, Darmstadt, Germany
Routinely and reproducibly generate high quality lipid nanoparticle formulations with RNA cargo for in vitro and in vivo assessmentApply novel protocols, processes, and analyses to optimize nanoparticle formulation, purification and analyticsOptimise final formulation buffers and excipients to improve the long-term stability of LNPs as well as scaling up of the LNP formulations Develop and characterize targeted LNP formulationsDevelop, run and optimize physicochemical characterization for nanoparticle formulation including Size/Charge (DLS), Encapsulation Efficiency, Endotoxin assessment and cargo protection assays.Support and perform in vitro cell-based assays to test nanoparticle activity, cargo expression and toxicity profilingAnalyze, summarize and present scientific results to the cross-functional teams and managementDraft SOPs for nanoparticle formulation, analytics and production, generate COAs on produced materialsCRO and CDMO HandlingDesign and contribute to in vivo studiesTrain junior team members
EDUCATION
Columbus Higher Secondary School
High School Degree, Physics, Chemistry & Biology
Duke University School of Medicine
Regulatory Affairs Training Program
University of Inland Norway
Master's degree, Applied & Commercial Biotechnology
Punjab Technical University
Bachelor of Pharmacy (B.Pharm.), Pharmacy
Medizinische Hochschule Hannover
Ph.D., RNA Therapeutics and Liver Regeneration
ABOUT RAJENDRA KHANAL
I am an experienced scientist with 5 years of experience in developing, establishing…
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